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Suppression of cone-driven responses by rods in the isolated frog retina

Published online by Cambridge University Press:  02 June 2009

Cun-Jian Dong ,
Hao-Hua Qian ,
John S. McReynolds ,
Xiong-Li Yang  and
Yu-Min Liu
Cun-Jian Dong
Affiliation:
Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai, China Department of Physiology, The University of Michigan, Ann Arbor
Hao-Hua Qian
Affiliation:
Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai, China
John S. McReynolds
Affiliation:
Department of Physiology, The University of Michigan, Ann Arbor
Xiong-Li Yang
Affiliation:
Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai, China
Yu-Min Liu
Affiliation:
Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai, China
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Abstract

The sensitivity of rod- and cone-driven responses was studied in the isolated frog retina during the period of rapid dark adaptation following a conditioning flash which bleached a negligible amount of visual pigment. Following a conditioning flash, cone-driven b-wave responses were first enhanced and then depressed. The time courses of the enhancement and subsequent depression of cone-drive responses varies greatly with the intensity and wavelength of the conditioning flash, but were identical when the conditioning' flashes were matched for equal excitation of 502 nm rods. These changes in cone-driven response sensitivity were correlated with the desensitization and recovery of rods following the conditioning flash. When signal transmission from rods to second-order cells was interrupted by the addition of L-glutamate, the conditioning flash did not produce the above-described enhancement and subsequent depression of long-wavelength receptor potential responses. The suppression of cone-driven response therefore appears to be due to a synaptically mediated influence from 502 nm rods which is maximal when the rods are in the dark-adapted state, with little or no contribution from 433 nm rods, and no involvement of the pigment epithelium.

Keywords

Isolated retinaRodConeRod-cone interactionFrogGlutamate
Type
Research Articles
Information
Visual Neuroscience , Volume 1 , Issue 4 , July 1988 , pp. 331 - 338
Copyright
Copyright © Cambridge University Press 1988

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