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Stratification of alpha ganglion cells and ON/OFF directionally selective ganglion cells in the rabbit retina

Published online by Cambridge University Press:  06 October 2005

JIAN ZHANG ,
WEI LI ,
HIDEO HOSHI ,
STEPHEN L. MILLS  and
STEPHEN C. MASSEY
JIAN ZHANG
Affiliation:
Department of Ophthalmology and Visual Science, University of Texas Medical School at Houston, Houston Current address of Jian Zhang: Cullen Eye Institute, Baylor College of Medicine, Houston, TX 77030
WEI LI
Affiliation:
Department of Ophthalmology and Visual Science, University of Texas Medical School at Houston, Houston Current address of Wei Li: Department of Ophthalmology, Northwestern Medical School, Chicago, IL 60611
HIDEO HOSHI
Affiliation:
Department of Ophthalmology and Visual Science, University of Texas Medical School at Houston, Houston
STEPHEN L. MILLS
Affiliation:
Department of Ophthalmology and Visual Science, University of Texas Medical School at Houston, Houston
STEPHEN C. MASSEY
Affiliation:
Department of Ophthalmology and Visual Science, University of Texas Medical School at Houston, Houston
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Abstract

The correlation between cholinergic sensitivity and the level of stratification for ganglion cells was examined in the rabbit retina. As examples, we have used ON or OFF α ganglion cells and ON/OFF directionally selective (DS) ganglion cells. Nicotine, a cholinergic agonist, depolarized ON/OFF DS ganglion cells and greatly enhanced their firing rates but it had modest excitatory effects on ON or OFF α ganglion cells. As previously reported, we conclude that DS ganglion cells are the most sensitive to cholinergic drugs. Confocal imaging showed that ON/OFF DS ganglion cells ramify precisely at the level of the cholinergic amacrine cell dendrites, and co-fasciculate with the cholinergic matrix of starburst amacrine cells. However, neither ON or OFF α ganglion cells have more than a chance association with the cholinergic matrix. Z-axis reconstruction showed that OFF α ganglion cells stratify just below the cholinergic band in sublamina a while ON α ganglion cells stratify just below cholinergic b. The latter is at the same level as the terminals of calbindin bipolar cells. Thus, the calbindin bipolar cell appears to be a prime candidate to provide the bipolar cell input to ON α ganglion cells in the rabbit retina. We conclude that the precise level of stratification is correlated with the strength of cholinergic input. Alpha ganglion cells receive a weak cholinergic input and they are narrowly stratified just below the cholinergic bands.

Keywords

RetinaInner plexiform layerConfocal microscopyAlpha ganglion cellsDirectional selectivityON/OFF DS ganglion cellsCholinergic amacrine cellsCalbindin bipolar cells
Type
Research Article
Information
Visual Neuroscience , Volume 22 , Issue 4 , July 2005 , pp. 535 - 549
Copyright
2005 Cambridge University Press

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