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Retinal microglia polarization in diabetic retinopathy

Published online by Cambridge University Press:  03 May 2021

Xin Li ,
Zi-Wei Yu ,
Hui-Yao Li ,
Yue Yuan ,
Xin-Yuan Gao  and
Hong-Yu Kuang
Xin Li
Affiliation:
The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People’s Republic of China
Zi-Wei Yu
Affiliation:
The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People’s Republic of China
Hui-Yao Li
Affiliation:
The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People’s Republic of China
Yue Yuan
Affiliation:
The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People’s Republic of China
Xin-Yuan Gao*
Affiliation:
The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People’s Republic of China
Hong-Yu Kuang
Affiliation:
The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People’s Republic of China
*
*Address correspondence to: Xin-Yuan Gao, Email: [email protected]
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Abstract

Microglia, the main immune cell of the central nervous system (CNS), categorized into M1-like phenotype and M2-like phenotype, play important roles in phagocytosis, cell migration, antigen presentation, and cytokine production. As a part of CNS, retinal microglial cells (RMC) play an important role in retinal diseases. Diabetic retinopathy (DR) is one of the most common complications of diabetes. Recent studies have demonstrated that DR is not only a microvascular disease but also retinal neurodegeneration. RMC was regarded as a central role in neurodegeneration and neuroinflammation. Therefore, in this review, we will discuss RMC polarization and its possible regulatory factors in early DR, which will provide new targets and insights for early intervention of DR.

Keywords

microglia polarizationretinal microgliadiabetic retinopathy
Type
Review Article
Information
Visual Neuroscience , Volume 38 , 2021 , E006
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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