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Prenatal disruption of binocular interactions creates novel lamination in the cat's lateral geniculate nucleus

Published online by Cambridge University Press:  02 June 2009

Preston E. Garraghty ,
Carla J. Shatz  and
Mriganka Sur
Preston E. Garraghty
Affiliation:
1Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge
Carla J. Shatz
Affiliation:
2 Department of Neurobiology, Stanford University School of Medicine, Stanford
Mriganka Sur
Affiliation:
1Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge
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Abstract

The elimination of retinogeniculate afferents from one eye on embryonic day 44 (E44) has pronounced effects on the formation of the cellular laminae in the cat lateral geniculate nucleus (LGN). Only two laminae form: a dorsal, “magnocellular” layer, and a ventral, “parvocellular” layer. Soma size measurements and previously reported patterns of termination of retinogeniculate axons suggest that the dorsal lamina is a coalescence of the normal A-laminae and the dorsal, magnocellular division of layer C, while the ventral layer is a composite of the parvocellular sublamina of layer C and the remaining C-laminae. This is a novel pattern of lamination in the LGN that differs from that found in the normal nucleus, not only in that there are now only two cell layers rather than the normal five, but also in that the interlaminar zone occurs in an abnormal location. This result is markedly different from that observed in other species where interlaminar zones present after early monocular enucleation are a subset of the ones which would normally be present. We suggest that, in the absence of ongoing binocular interactions, interactions between functionally distinct retinal ganglion cell classes from the remaining eye may direct the formation of cell laminae in the LGN, even when such interactions are not normally operative.

Keywords

CatLateral geniculate nucleusVisual developmentLaminationBinocular interactions
Type
Research Articles
Information
Visual Neuroscience , Volume 1 , Issue 1 , January 1988 , pp. 93 - 102
Copyright
Copyright © Cambridge University Press 1988

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