Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-23T04:29:58.504Z Has data issue: false hasContentIssue false
  • English
  • Français

GABA responses of rod bipolar cells in rabbit retinal slices

Published online by Cambridge University Press:  01 May 2000

GREGORY S. McGILLEM ,
THOMAS C. ROTOLO  and
RAMON F. DACHEUX
GREGORY S. McGILLEM
Affiliation:
Callahan Eye Foundation Hospital, Department of Ophthalmology, University of Alabama at Birmingham, Birmingham
THOMAS C. ROTOLO
Affiliation:
Callahan Eye Foundation Hospital, Department of Ophthalmology, University of Alabama at Birmingham, Birmingham
RAMON F. DACHEUX
Affiliation:
Callahan Eye Foundation Hospital, Department of Ophthalmology, University of Alabama at Birmingham, Birmingham
Get access Rights & Permissions [Opens in a new window]

Abstract

GABAergic responses of rabbit rod bipolar cells were reexamined by using whole-cell recordings in the superfused slice preparation to determine if there is GABAC receptor input to their axon terminal and to characterize the contribution that GABAA and GABAC receptors make to the total GABA current on the axon terminals of these cells. Pharmacological agents specifically blocking GABAA and GABAC receptor currents demonstrated that 37% of the GABA-activated current was blocked by either the GABAA antagonists bicuculline or SR-95531, whereas the remaining 63% of the GABA current was blocked by a mixture of bicuculline and the GABAC antagonist TPMPA. This indicated that GABAC receptors were present on the axon terminal of the rabbit rod bipolar cell and that they were responsible for mediating the bicuculline insensitive GABA current.

Keywords

Rabbit retinaRod bipolar cellsWhole-cell patch-clamp recordingGABAA receptorsGABAC receptors
Type
Research Article
Information
Visual Neuroscience , Volume 17 , Issue 3 , May 2000 , pp. 381 - 389
Copyright
2000 Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)