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Functional architecture of area 17 in normal and monocularly deprived marmosets (Callithrix jacchus)

Published online by Cambridge University Press:  02 June 2009

Frank Sengpiel ,
David Troilo ,
Peter C. Kind ,
Bryan Graham  and
Colin Blakemore
Frank Sengpiel
Affiliation:
University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, UK
David Troilo
Affiliation:
University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, UK
Peter C. Kind
Affiliation:
University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, UK
Bryan Graham
Affiliation:
University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, UK
Colin Blakemore
Affiliation:
University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, UK
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Abstract

The organization of the primary visual cortex (VI) of the common marmoset (Callithrix jacchus) was studied both physiologically and by means of transneuronal labelling of geniculocortical afferents. We addressed the question whether monocular deprivation (MD) could stabilize segregation into ocular dominance (OD) columns, which are not seen in normal adult marmosets but are present in juvenile animals (Spatz, 1979, 1989). Properties of neurons in normal marmosets closely resembled those of other New-World and Old-World monkeys and orderly tangential progressions of preferred orientation were observed. However, in contrast to species that display well-defined OD columns, neurons of layer 4 in VI of normal adult marmosets received balanced inputs from the two eyes. Early MD (even though followed by prolonged binocular experience into adulthood) resulted in a reduction of cell size in laminae of the lateral geniculate nucleus with input from the deprived eye and a dramatic overall shift in ocular dominance towards the non-deprived eye in the cortex. However, isolated clusters of cells dominated by the deprived eye were found in both layers 4 and 6. Injection of lectin-conjugated horseradish peroxidase (WGA-HRP) into the deprived eye revealed elongated patches of terminal label, about 350 μm wide, in flat-mounted sections through layer 4. Afferent segregation was sharper and more regular in the region of VI representing parafoveal visual space than in that representing the fovea. Our findings support the notion that all Old-World and New-World monkeys possess the capacity for segregation of geniculocortical afferents into OD columns.

Keywords

New-World monkeyMarmosetPrimary visual cortexOcular dominance columnsMonocular deprivationOrientation columns
Type
Research Articles
Information
Visual Neuroscience , Volume 13 , Issue 1 , January 1996 , pp. 145 - 160
Copyright
Copyright © Cambridge University Press 1996

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