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Distribution of cholinergic amacrine cells in the retinas of normally pigmented and hypopigmented strains of rat and cat

Published online by Cambridge University Press:  02 June 2009

John Mitrofanis  and
Jonathan Stone
John Mitrofanis
Affiliation:
School of Anatomy, University of New South Wales and Department of Anatomy, University of Sydney
Jonathan Stone
Affiliation:
School of Anatomy, University of New South Wales and Department of Anatomy, University of Sydney
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Abstract

We have examined the soma size, number, and distribution of cholinergic amacrine cells in the retinas of albino and pigmented rats and of Siamese and common cats, using an antibody against choline acetyl transferase (ChAT). In the pigmented strains of rat and cat, ChAT-immunoreactive (ChAT-IR) somata were located in both the inner part of the inner nuclear layer (INL) and ganglion cell layer (GCL), and their processes spread in distinct strata of the inner plexiform layer (IPL). The diameters of the somata in the INL and GCL did not differ significantly at any retinal location. Furthermore, soma diameter did not vary with eccentricity, except at the area centralis of the common cat, where ChAT-IR somata in both layers were relatively smaller. In both species, ChAT-IR somata in the GCL outnumbered those in the INL at all retinal locations. Both populations of cells tended to concentrate at the area of peak ganglion cell density and along the visual streak. Additionally, areas of relatively high density extended superiorly from the area of peak density. The same features of morphology and distribution were identifiable in the hypopigmented strains of rat and cat, but the numbers of ChAT-IR cells were consistently higher.

Keywords

Amacrine cellsCholine acetyl transferaseSiamese cat
Type
Research Articles
Information
Visual Neuroscience , Volume 1 , Issue 4 , July 1988 , pp. 367 - 376
Copyright
Copyright © Cambridge University Press 1988

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References

Adams, J.C. (1981). Heavy metal intensification of DAB-based HRP reaction product. Journal of Histochemistry and Cytochemistry 29, 775.CrossRefGoogle ScholarPubMed
Ariel, M. & Daw, N.W. (1982 a). Effects of cholinergic drugs on receptive field properties of rabbit retinal ganglion cells. Journal of Physiology 324, 135–160.CrossRefGoogle ScholarPubMed
Ariel, M. & Daw, N.W. (1982 b). Pharmacological analysis of directionally sensitive rabbit retinal ganglion cells. Journal of Physiology 324, 161–185.CrossRefGoogle ScholarPubMed
Brandon, C. (1987). Cholinergic neurons in the rabbit retina: immunocytochemical localization, and relationship to GaBAergic and cholinesterase-containing neurons. Brain Research 401, 385–391.CrossRefGoogle ScholarPubMed
Chino, Y.M., Shansky, M.S. & Hamasaki, D.I. (1981). Properties of X- and Y-type ganglion cells in Siamese cats. Brain Research 143, 459–473.CrossRefGoogle Scholar
Cleland, B.G. & Levick, W.R. (1974 a). Brisk and sluggish concentrically organized ganglion cells in the cat's retina. Journal of Physiology 240, 421–456.Google Scholar
Cleland, B.G. & Levick, W.R. (1974 b). Properties of rarely encountered types of ganglion cells in the cat's retina and an overall classification. Journal of Physiology 240, 457–492.Google Scholar
Dreher, B., Potts, R.a., Ni, S.Y.K. & Bennett, M.R. (1984). The development of heterogeneities in distribution and soma sizes of rat retinal ganglion cells. In Development of Visual Pathways in Mammals, Neurology and Neurobiology 9, ed. Stone, J., Dreher, B., Rapaport, D.H., pp. 39–57. New York: alan R. Liss.Google Scholar
Dreher, B., Sefton, a.J., Ni, S.Y.K. & Nisbett, G. (1985). The morphology, number, distribution, and central projections of class 1 ganglion cells in albino and pigmented rats. Brain Behaviour and Evolution 26, 10–48.Google Scholar
Eckstein, F., Barde, Y.a. & Theonen, H. (1981). Production of specific antibodies to choline acetyl transferase purified from pig brain. Neuroscience 6, 993–1000.CrossRefGoogle Scholar
Eckenstein, F. & Theonen, H. (1981). Choline acetyl transferase: purification and immunofluorescent localization in the retina of four vertebrate species. Society of Neuroscience abstracts 7, 309.Google Scholar
Fukuda, Y. (1977). a three group classification of rat retinal ganglion cells: histological and physiological studies. Brain Research 119, 324–344.CrossRefGoogle ScholarPubMed
Halasz, P. & Martin, P. (1984). a microcomputer based system for semiautomatic analysis of histochemical sections. Royal Microscopic Society Proceedings 19, 312.Google Scholar
Hayden, S.A., Mills, J.W. & Masland, R.H. (1980). acetylcholine synthesis by displaced amacrine cells. Science 210, 435–437.Google Scholar
Hughes, A. & Wieniawa-Narkiewicz, E. (1980). a newly identified population of presumptive microneurons in the cat retinal ganglion cell layer. Nature 284, 468–470.Google Scholar
Kondo, H., Kuramoto, H., Wainer, B.H. & Yanaihara, N. (1985). Discrete distribution of cholinergic and vasoactive intestinal poly-peptidergic amacrine cells in the rat retina. Neuroscience Letters 54, 213–218.CrossRefGoogle ScholarPubMed
Masland, R.H. & Ames, A. (1976). Response to acetylcholine of ganglion cells in an isolated mammalian retina. Journal of Neuro-physiology 39, 1220–1235.CrossRefGoogle Scholar
Masland, R.H. & Mills, J.W. (1979). Autoradiographic identification of acetylcholine in the rabbit retina. Journal of Cell Biology 83, 159–178.CrossRefGoogle ScholarPubMed
Masland, R.H., Mills, J.W. & Cassidy, C. (1984 a). The functions of acetylcholine in the rabbit retina. Proceedings of the Royal Society (London) Biology 223, 121–129.Google ScholarPubMed
Masland, R.H., Mills, J.W. & Hayden, S.A. (1984 b). acetylcholine- synthesizing amacrine cells: identification and selective staining by using radiography and fluorescent markers. Proceedings of the Royal Society (London) Biology 223, 79–100.Google Scholar
Masland, R.H. & Tauchi, M. (1986). The cholinergic amacrine cell. Trends in Neuroscience 9, 218–223.CrossRefGoogle Scholar
Mastronarde, D.N., Thibeault, M.A. & Dubin, M.W. (1984). Non-uniform postnatal growth of the cat retina. Journal of Comparative Neurology 228, 598–608.CrossRefGoogle ScholarPubMed
McCall, M.J., Robinson, S.R. & Dreher, B. (1987). Differential cell growth appears to be the primary factor producing the ganglion cell density gradient in the rat. Neuroscience Letters 79, 78–84.CrossRefGoogle ScholarPubMed
Mitrofanis, J., Vigny, A. & Stone, J. (1988). Distribution of cate-cholaminergic cells in the retinas of the rat, guinea pig, cat, and rabbit: independence from ganglion cell distribution. Journal of Comparative Neurology 267, 1–14.CrossRefGoogle Scholar
Morgan, I.G., Oliver, J. & Chubb, I.W. (1981). Discrete distributions of putative cholinergic and somatostatinergic amacrine cell dendrites in chicken retina. Neuroscience Letters 27, 55–60.Google Scholar
Perry, V.H., Henderson, Z. & Linden, R. (1983). Postnatal changes in retinal ganglion cell and optic axon populations in the pigmented rat. Journal of Comparative Neurology 219, 356.CrossRefGoogle ScholarPubMed
Pourcho, R.G. & Osman, K. (1986). Cytochemical identification of cholinergic amacrine cells in cat retin. Journal of Comparative Neurology 247, 497–504.Google Scholar
Puro, D.G., Batelle, B.a. & Hansmann, K.E. (1982). Development of cholinergic neurons of the rat retina. Developmental Biology 91, 138–148.CrossRefGoogle ScholarPubMed
Rapaport, D.H. & Stone, J. (1983). Time course of morphological differentiation of cat retinal ganglion cells. Journal of Comparative Neurology 221, 42–52.Google Scholar
Robinson, S.R. (1985). Cytogenesis and cell death during cat retinal development. Ph.D. Thesis, University of New South Wales.Google Scholar
Robinson, S.R. (1987). Ontogeny of the area centralis in the cat. Journal of Comparative Neurology 255, 50–67.CrossRefGoogle ScholarPubMed
Ross, C.D., Dunning, D.P., Juengal, L.I. & Godfrey, D.a. (1985). Laminar distributions of choline acetyl transferase and acetyl cholinesterase activities in the inner plexiform layer. Journal of Neurochemistry 44, 1091–1099.CrossRefGoogle Scholar
Schmidt, M., Wassle, H. & Humphrey, M. (1985). Number and distribution of putative cholinergic neurons in the cat retina. Neuroscience Letters 59, 235–240.CrossRefGoogle ScholarPubMed
Stone, J. (1978). The number and distribution of ganglion cells in the cat's retina. Journal of Comparative Neurology 180, 753–772.CrossRefGoogle ScholarPubMed
Stone, J. (1981). The Wholemount Handbook. Sydney: Maitland.Google Scholar
Stone, J., Rapaport, D.H., Williams, R. & Chalupa, L. (1982). Uniformity of cell distribution in the ganglion cell layer of the prenatal cat retina: implications for mechanisms of retinal development. Developmental Brain Research 2, 231–242.CrossRefGoogle Scholar
Stone, J., Rowe, M.H. & Campion, J.E. (1978 a). Retinal abnormalities in the Siamese cat. Journal of Comparative Neurology 180, 773–782.CrossRefGoogle ScholarPubMed
Stone, J., Campion, J.E. & Leicester, J. (1978 b). The naso-temporal division of retina in Siamese cat. Journal of Comparative Neurology 180, 753–772.Google Scholar
Tauchi, M. & Masland, R.H. (1984). The shape and arrangement of the cholinergic neurons in the rabbit retina. Proceedings of the Royal Society (London) Biology 223, 101–109.Google Scholar
Vaney, D.I. (1984). “Coronate” amacrine cells in the rabbit retina have the “starburst” dendritic morphology. Proceedings of the Royal Society (London) Biology 220, 501–508.Google Scholar
Vaney, D.I. (1985). The morphology and topographic distribution of all amacrine cells in the cat retina. Proceedings of the Royal Society (London) Biology 224, 475–488.Google Scholar
Vaney, D.I., Levick, W.R. & Thibos, L.N. (1981 a). Rabbit retinal ganglion cells. Experimental Brain Research 44, 27–33.CrossRefGoogle ScholarPubMed
Vaney, D.I., Peichel, L. & Boycott, B.B. (1981 b). Matching populations of amacrine cells in the inner nuclear layer and ganglion cell layer of the rabbit retina. Journal of Comparative Neurology 199, 373–391.Google Scholar
Voigt, T. (1986). Cholinergic amacrine cells in the rat retina. Journal of Comparative Neurology 248, 19–35.CrossRefGoogle ScholarPubMed
Wassle, H., Boycott, B.B. & Illing, R.B. (1981). Morphology and mosaic of on- and off-beta cells in the cat retina and some functional considerations. Proceedings of the Royal Society (London) Biology 212, 177–195.Google Scholar
Wong, R.O.L. & Hughes, a. (1987). The morphology, number, and distribution of a large population of confirmed displaced amacrine cells in the adult cat retina. Journal of Comparative Neurology 255, 159–177.Google Scholar
Zamboni, L. & Demartino, C. (1967). Buffered picric acid-formaldehyde: a new, rapid fixative for electron microscopy. Journal of Cell Biology 35, 148A.Google Scholar