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Contour integration in amblyopic monkeys

Published online by Cambridge University Press:  22 January 2004

PETRA KOZMA  and
LYNNE KIORPES
PETRA KOZMA
Affiliation:
Retina Foundation of the Southwest, Dallas
LYNNE KIORPES
Affiliation:
Center for Neural Science, New York University, New York
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Abstract

Amblyopia is characterized by losses in a variety of aspects of spatial vision, such as acuity and contrast sensitivity. Our goal was to learn whether those basic spatial deficits lead to impaired global perceptual processing in strabismic and anisometropic amblyopia. This question is unresolved by the current human psychophysical literature. We studied contour integration and contrast sensitivity in amblyopic monkeys. We found deficient contour integration in anisometropic as well as strabismic amblyopic monkeys. Some animals showed poor contour integration in the fellow eye as well as in the amblyopic eye. Orientation jitter of the elements in the contour systematically decreased contour-detection ability for control and fellow eyes, but had less effect on amblyopic eyes. The deficits were not clearly related to basic losses in contrast sensitivity and acuity for either type of amblyopia. We conclude that abnormal contour integration in amblyopes reflects disruption of mechanisms that are different from those that determine acuity and contrast sensitivity, and are likely to be central to V1.

Keywords

Contour integrationAmblyopiaNonhuman primate
Type
Research Article
Information
Visual Neuroscience , Volume 20 , Issue 5 , September 2003 , pp. 577 - 588
Copyright
2003 Cambridge University Press

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