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APB Selectively Reduces Visual Responses in Goldfish to High Spatiotemporal Frequencies

Published online by Cambridge University Press:  02 June 2009

Paul J. DeMarco Jr ,
Jonathan D. Nussdorf ,
Douglas A. Brockman  and
Maureen K. Powers
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Abstract

Visual responses of goldfish to rotating square-wave gratings were recorded before and after intraocular injection of 2-amino-4-phosphonobutyric acid (APB). High doses of APB reduced the rate of optokinetic nystagmus (OKN) to a relatively high spatial frequency grating moving at a high temporal frequency. Responses to a low spatial frequency grating were not altered, nor were responses to the higher spatial frequency when it rotated slowly. The effects of APB were transient and lasted no longer than 3 d. We conclude that APB reduces OKN to high spatiotemporal frequencies in goldfish.

Keywords

Spatiotemporal visionOptokinetic nystagmus2-amino-4-phosphonobutyric acidON/OFF pathwaysGoldfish
Type
Research Articles
Information
Visual Neuroscience , Volume 2 , Issue 1 , January 1989 , pp. 15 - 18
Copyright
Copyright © Cambridge University Press 1989

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