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Amacrine-to-amacrine cell inhibition: Spatiotemporal properties of GABA and glycine pathways

Published online by Cambridge University Press:  07 June 2011

XIN CHEN ,
HAIN ANN HSUEH  and
FRANK S. WERBLIN
XIN CHEN
Affiliation:
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California
HAIN ANN HSUEH
Affiliation:
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California
FRANK S. WERBLIN*
Affiliation:
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California
*
*Address correspondence and reprint requests to: Frank S. Werblin, Werblin Lab, University of California, Berkeley, Department of Molecular & Cell Biology, 142 Life Sciences Addition # 3200, Berkeley, CA 94720-3200.
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Abstract

We measured the spatial and temporal properties of GABAergic and glycinergic inhibition to amacrine cells in the whole-mount rabbit retina. The amacrine cells were parsed into two morphological classes: narrow-field cells with processes spreading less than 200 μm and wide-field cells with processes extending more than 300 μm. The inhibition was also parsed into two types: sustained glycine and transient GABA. Narrow-field amacrine cells receive 1) very transient GABAergic inhibition with a fast onset latency of 140 ± 16 ms decaying to 30% of the peak level within 208 ± 27 ms elicited broadly over a lateral distance of up to 1500 μm and 2) sustained glycinergic inhibition with a medium onset latency of 286 ± 23 ms that was elicited over a spatial area often broader than the processes of the narrow-field amacrine cells. Wide-field amacrine cells received sustained glycinergic inhibition but no broad transient GABAergic inhibition. Surprisingly, neither of these amacrine cell classes received sustained local GABAergic inhibition, commonly found in an earlier study of ganglion cells.

Type
Research Articles
Information
Visual Neuroscience , Volume 28 , Issue 3 , May 2011 , pp. 193 - 204
Copyright
Copyright © Cambridge University Press 2011

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