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Albino gene dosage and retinal decussation patterns in the pigmented ferrret

Published online by Cambridge University Press:  02 June 2009

I. D. Thompson ,
G. Jeffery ,
J. E. Morgan  and
G. Baker
I. D. Thompson
Affiliation:
University Labortory of Physiology, Parks Road Oxford, U.K.
G. Jeffery*
Affiliation:
Department of Human Antomy, South Parks Road, Oxford, U.K.
J. E. Morgan
Affiliation:
University Labortory of Physiology, Parks Road Oxford, U.K.
G. Baker
Affiliation:
Department of Human Antomy, South Parks Road, Oxford, U.K.
*
Current address of G. Jeffery: Department Visual Science, Institute of Ophthalmology, Judd Street, London WCIH 9QS, U.K.
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Abstract

We have examined the retinal decussation patterns in pigmented ferrets that were either wild-type sable or heterozygous with one albino gene. Unilateral injections of horseradish peroxidase were made into the optic tract and labeled ganglion cells visualized in retinal wholemounts. In both wild-type and heterozygous ferrets, those ganglion cells in the temporal retina with the largest cell bodies projected only to the contralateral side of the brain. The total number of ipsilaterally projecting ganglion cells did not differ with the genotype of the animal. The numbers ranged from 5471–6759 cells. Unlike the cat, there is no difference in retinal decussation patterns in wild-type sable ferrets and heterozygous ferrets carrying one albino gene.

Keywords

Retinal DecussationRetinal pigmentAlbinismRetinal ganglion cellsHeterozygote
Type
Research Articles
Information
Visual Neuroscience , Volume 6 , Issue 4 , April 1991 , pp. 393 - 398
Copyright
Copyright © Cambridge University Press 1991

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References

Cooper, M.L. & Pettigrew, J.D. (1979). The retinothalamic pathways in Siamese cats. Journal of Comparative Neurology 187, 313–348.CrossRefGoogle ScholarPubMed
Creel, D., Hendrickson, A.E. & Leventhal, A.G. (1982). Retinal projections in tyrosinase-negative cats. Journal of Neuroscience 2, 907–911.Google Scholar
Eldridge, J.L., Morgan, J.E. & Thompson, I.D. (1985). A versatile mammalian stereotaxic headholder for visual europhysiology. Journal of Physiology 358, 2P.Google Scholar
Guilery, R.W. (1971). An abnormal retinogeniculate projection in the albino ferret. Brain Research 33, 482–485.CrossRefGoogle Scholar
Guillery, R.W. (1986). Neural abnormalities of albinos. Trends in Neuroscience 9, 364–367.Google Scholar
Guillery, R.W. & Kaas, J.H. (1971). A study of normal and congenitally abnormal retinogeniculate projections in cats. Journal of Comparative Neurology 143, 73–100.CrossRefGoogle ScholarPubMed
Guillery, R.W.Jeffery, G. & Cattanach, B.M. (1987). Abnormally high variability in the uncrossed retinofugal pathway of mice with albino mosaicism. Development 101, 857–867.Google Scholar
King, R.A. & Wrtkop, C.J. (1977). Detection of heterozygotes for tyrosinase-negative oculocutaneous albinism by hairbulb tyrosinase assay. American Journal of Human Genetics 29, 164–168.Google ScholarPubMed
LaVail, J.H., Nixon, R.A. & Sidman, R.L. (1978). Genetic control of retinal ganglion cell projections. Journal of Comparative Neurology 149, 399–422.Google Scholar
Leventhal, A.G. & Creel, D.J. (1985). Retinal projections and functional architecture of cortical areas 17 and 18 in the tyrosinase-negative albino cat. Journal of Neuroscience 5, 795–807.Google Scholar
Leventhal, A.G., Vitek, D.J. & Creel, D.J. (1985). Abnormal visual pathways in normal pigmented cats that are heterozygous for albinism. Science 229, 1395–1397.CrossRefGoogle ScholarPubMed
Lund, R.D. (1965). Uncrossed visual pathways in hooded and albino rats. Science 149, 1506–1507.Google Scholar
Lund, R.D. (1975). Variations in the laterality of the central projections of retinal ganglion cells. Experimental Eye Research 21, 193–203.CrossRefGoogle ScholarPubMed
Morgan, J.E., Henderson, Z. & Thompson, I.D. (1987). Retinal decussation patterns in pigmented and albion ferrets. Neuroscience 20, 519–535.CrossRefGoogle Scholar
Perry, V.H. & Linden, R. (1982). Evidence for dendritic competition in the developing retina. Nature 297, 683–685.CrossRefGoogle ScholarPubMed
Reese, B.E. & Baker, G.E. (1990). The course of fibre diameter classes through the chiasmatic region in the ferret. European Journal of Neuroscience 2, 34–49.CrossRefGoogle ScholarPubMed
Sanderson, K.J., Guillery, R.W. & Shackelford, R.M. (1974). Congenitally abnormal visual pathways in mink (Mustela vision) with reduced retinal pigment. Journal of Comparative Neurology 154, 225–248.CrossRefGoogle ScholarPubMed
Serale, A.G. (1968). Comparative Genetics of Coat Colour in Mammals. New York: Academic Press.Google Scholar
Stone, J., Campion, J.E. & Leicester, J. (1978). The nasotemporal division of retina in the Siamese cat. Journal of Comparative Neurology 180, 783–798.Google Scholar
Stone, J., Dreher, B. & Leventhal, A.G. (1979). Parallel and hierarchical mechanisms in the organization of visual cortex. Brain Research Reviews 1, 345–394.Google Scholar
Vitek, D.J., Schall, J.D. & Leventhal, A.G. (1985). Morphology, central projections, and dendritic-field orientation of retinal ganglion cells in the ferret. Journal of Comparative Neurology 241, 1–11.Google Scholar
Walsh, C., Polley, E.H., Hickey, T.L. & Guillery, R.W. (1983). Generation of cat retinal ganglion cells in relation to central pathways. Nature 302, 611–614.Google Scholar