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The ageing photoreceptor

Published online by Cambridge University Press:  19 July 2007

ALEXANDER CUNEA  and
GLEN JEFFERY
ALEXANDER CUNEA
Affiliation:
Institute of Ophthalmology, University College London, UK University of Heidelberg, Heidelberg, Germany
GLEN JEFFERY
Affiliation:
Institute of Ophthalmology, University College London, UK
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Abstract

With age many retinal neurons are lost. In humans the rod photoreceptor population in the perimacular region is subject to approximately 30% loss over life. Those that remain have been reported to suffer from extensive convolutions and localized swellings of their outer segments abnormally increasing their disc content and outer segment length. Here we examine quantitatively age-related changes in rat rod photoreceptors. The rat retina is ∼97% rod dominated. Here, aged rods showed significant reductions in outer segment length. The discs in their outer segments had a similar density, irrespective of whether they were young or old, however, in aged animals a higher proportion were misregistered. Surprisingly, in all of the tissue examined, we found no evidence for any convolution of outer segments or localized swelling as reported in humans, rather all remained straight. There are methodological differences between the research reported here and that undertaken on human retinae. There are also major differences in overall retinal architecture between humans and rodents that could contribute to differences in the aging process of individual cells. If it is the case that individual photoreceptors age differently in rodents compared to humans, it may pose significant problems for the use of this animal model in studies of ageing and age related outer retinal disease.

Keywords

RetinaAgeingRod photoreceptorOuter segment
Type
Research Article
Information
Visual Neuroscience , Volume 24 , Issue 2 , March 2007 , pp. 151 - 155
Copyright
2007 Cambridge University Press

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References

REFERENCES

Alamouti, B. & Funk, J. (2003). Retinal thickness decreases with age: An OCT study. The British Journal of Ophthalmology 87, 899–901.CrossRefGoogle Scholar
Curcio, C.A. & Drucker, D.N. (1993). Retinal ganglion cells in Alzheimer's disease and aging. Annals of Neurology 33, 248–257.CrossRefGoogle Scholar
Curcio, C.A., Millican, C.L., Allen, K.A. & Kalina, R.E. (1993). Aging of the human photoreceptor mosaic: Evidence for selective vulnerability of rods in central retina. Investigative Ophthalmology & Visual Science 34, 3278–3296.Google Scholar
Fox, D.A. & Rubinstein, S.D. (1989). Age-related changes in retinal sensitivity, rhodopsin content and rod outer segment length in hooded rats following low-level lead exposure during development. Experimental Eye Research 48, 237–249.CrossRefGoogle Scholar
Gao, H. & Hollyfield, J.G. (1992). Aging of the human retina. Differential loss of neurons and retinal pigment epithelial cells. Investigative Ophthalmology & Visual Science 33, 1–17.Google Scholar
Goldman, A.I. (1982). The sensitivity of rat rod outer segment disc shedding to light. Investigative Ophthalmology & Visual Science 22, 695–700.Google Scholar
Gresh, J., Goletz, P.W., Crouch, R.K. & Rohrer, B. (2003). Structure-function analysis of rods and cones in juvenile, adult, and aged C57bl/6 and Balb/c mice. Visual Neuroscience 20, 211–220.CrossRefGoogle Scholar
Hughes, A. (1977). The Topography of Vision in Mammals of Contrasting Life Style: Comparative Optics and Retinal Organisation, vol. VII/5. Springer Verlag, Berlin.
Jackson, G.R., McGwin, G., Phillips, J.M., Klein, R. & Owsley, C. (2004). Impact of aging and age-related maculopathy on activation of the a-wave of the rod-mediated electroretinogram. Investigative Ophthalmology & Visual Science 45, 3271–3278.CrossRefGoogle Scholar
Jackson, G.R., McGwin, G., Phillips, J.M., Klein, R. & Owsley, C. (2006). Impact of aging and age-related maculopathy on inactivation of the a-wave of the rod-mediated electroretinogram. Vision Research 46, 1422–1431.CrossRefGoogle Scholar
Katz, M.A. & Robison, W.G. (1986). Evidence of cell loss from the rat retina during senescence. Experimental Eye Research 42, 293–304.CrossRefGoogle Scholar
LaVail, M.M. (1980). Circadian nature of rod outer segment disc shedding in the rat. Investigative Ophthalmology & Visual Science 19, 407–411.Google Scholar
Li, D., Sun, F. & Wang, K. (2003). Caloric restriction retards age-related changes in rat retina. Biochemical and Biophysical Research Communications 309, 457–463.CrossRefGoogle Scholar
Marshall, J., Grindle, J., Ansell, P.L. & Borwein, B. (1979). Convolution in human rods: An ageing process. The British Journal of Ophthalmology 63, 181–187.CrossRefGoogle Scholar
Schremser, J.L. & Williams, T.P. (1995). Rod outer segment (ROS) renewal as a mechanism for adaptation to a new intensity environment. I. Rhodopsin levels and ROS length. Experimental Eye Research 61, 17–23.Google Scholar
Spear, P.D. (1993). Neural bases of visual deficits during aging. Vision Research 33, 2589–2609.CrossRefGoogle Scholar
Walls, G.L. (1942). The Vertebrate Eye and its Adaptive Radiation. Bloomfield Hills, MI: The Cranbook Institute of Science.
Weisse, I. (1995). Changes in the aging rat retina. Ophthalmic Research 27, 154–163.CrossRefGoogle Scholar
Wright, C.E., Williams, D.E., Prasdo, N. & Harding, G.F.A. (1985). The influence of age on the spatial and temporal contrast sensitivity function. Documenta Ophthalmologica. Advances in Ophthalmology 59, 385–395.CrossRefGoogle Scholar