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X- and Y-mediated synaptic potentials in neurons of areas 17 and 18 of cat visual cortex

Published online by Cambridge University Press:  02 June 2009

David Ferster
David Ferster
Affiliation:
Department of Neurobiology and Physiology, Northwestern University, Evanston
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Abstract

When a cuff-shaped electrode is placed on the optic nerve of the cat, X and Y axons, by virtue of their different diameters, exhibit different thresholds to electrical stimulation. Large-diameter Y axons have low thresholds, while smaller-diameter X axons have high thresholds. There is very little overlap between the two populations. Given this segregation, the strength of stimulation of the optic nerve required to evoke synaptic potentials in cortical neurons becomes a reliable indicator of the type of visual input a cortical neuron receives. Potentials with thresholds below the thresholds of X axons must be mediated by Y cells of the retina and LGN. Potentials with thresholds above the Y axons of the optic nerve must be mediated by X cells. From previous experiments, one would expect ot find &le input via both types of axon to are 17 of the visual cortex. This was not the case. Of 58 neurons distributed throughout the layers of area 17 from which intracellular records were taken, in only four could substantial Y excitation be detected. Three of these four were located near the border with area 18. All four received large X inputs as well. The 24 neurons studied in area 18 all received large Y inputs but no detectable X input.

Keywords

Visual cortexX cellsY cells
Type
Research Articles
Information
Visual Neuroscience , Volume 4 , Issue 2 , February 1990 , pp. 115 - 133
Copyright
Copyright © Cambridge University Press 1990

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References

Bishop, G.H. & Heinbecker, P. (1930). Differentiation of axon types in visceral nerves by means of the potential record. American Journal of Physiology 94, 170–200.CrossRefGoogle Scholar
Bishop, P.O. & McLeod, J.G. (1954). Nature of potentials associated with synaptic transmission in lateral geniculate nucleus of cat. Journal of Neurophysiology 17, 387–414.CrossRefGoogle Scholar
Blair, E.A. & Erlanger, J. (1933). A comparison of the characteristics of axons through their individual electrical responses. American Journal of Physiology 106, 524–564.CrossRefGoogle Scholar
Bradley, K. & Eccles, J.C. (1953). Analysis of the fast afferent impulses from thigh muscles. Journal of Physiology (London), 122, 462–473.CrossRefGoogle ScholarPubMed
Bullier, J. & Henry, G.H. (1979 a). Laminar distribution of first-order neurons and afferent terminals in cat striate cortex. Journal of Neurophysiology 42, 1271–1281.CrossRefGoogle ScholarPubMed
Bullier, J. & Henry, G.H. (1979 b). Neuronal path taken by afferent streams in striate cortex of the cat. Journal of Neurophysiology 42, 1264–1270.CrossRefGoogle ScholarPubMed
Cleland, B.G., Dubin, M.W. & Levick, W.R. (1971). Sustained and transient neurones in the cat's retina and lateral geniculate nucleus. Journal of Physiology (London) 217, 473–496.CrossRefGoogle ScholarPubMed
Cleland, B.G. & Lee, B.B. (1985). A comparison of visual responses of cat lateral geniculate nucleus neurones with those of ganglion cells afferent to them. Journal of Physiology (London) 369, 249–268.CrossRefGoogle Scholar
Derrington, A.M. & Fuchs, A.F. (1979). Spatial and temporal properties of X and Y cells in the cat lateral geniculate nucleus. Journal of Physiology (London) 293, 347–364.CrossRefGoogle ScholarPubMed
Dreher, B., Leventhal, A.G. & Hale, P.T. (1980). Geniculate input to cat visual cortex. Journal of Neurophysiology 44, 804–826.CrossRefGoogle ScholarPubMed
Eccles, J.C., Eccles, R.M. & Lundberg, A. (1957). Synaptic actions on motoneurones in relation to the two components of the group I muscle afferent volley. Journal of Physiology (London) 136, 527–546.CrossRefGoogle Scholar
Enroth-Cugell, C. & Robson, J.G. (1966). The contrast sensitivity of retinal ganglion cells of the cat. Journal of Physiology (London) 187, 517–552.CrossRefGoogle ScholarPubMed
Ferster, D. (1990). X- and Y-mediated current sources in areas 17 and 18 of cat visual cortex. Visual Neuroscience 4, 135–145.CrossRefGoogle ScholarPubMed
Ferster, D. & LeVay, S. (1978). The axonal arborization of lateral geniculate neurons in the striate cortex of the cat. Journal of Comparative Neurology 182, 923–944.CrossRefGoogle ScholarPubMed
Ferster, D. & Lindström, S. (1983). An intracellular analysis of geniculocortical connectivity in area 17 of the cat. Journal of Physiology (London) 342, 181–215.CrossRefGoogle ScholarPubMed
Freund, T.F., Martin, K.A.C. & Whitteridge, D. (1985). Innervation of cat visual areas 17 and 18 by physiologically identified X- and Y-type thalamic afferents, I: Arborization patterns and quantitative distribution of postsynaptic elements. Journal of Comparative Neurology 242, 263–274.CrossRefGoogle ScholarPubMed
Gilbert, C.D. & Wiesel, T.N. (1979). Morphology and intracortical projections of functionally characterized neurons in the cat visual cortex. Nature 280, 120–125.CrossRefGoogle ScholarPubMed
Hochstein, S. & Shapley, R.M. (1976). Quantitative analysis of retinal ganglion cell classifications. Journal of Physiology (London) 262, 237–264.CrossRefGoogle ScholarPubMed
Hoffman, K.-P., Stone, J. & Sherman, S.M. (1972). Relay of receptive-field properties in dorsal lateral geniculate nucleus of the cat. Journal of Neurophysiology 35, 518–531.CrossRefGoogle Scholar
Hoffman, K.P. & Stone, J. (1971). Conduction velocity of afferents to cat visual cortex: a correlation with cortical receptive-field properties. Brain Research 32, 460–466.CrossRefGoogle ScholarPubMed
Humphrey, A.L., Sur, M., Uhlrich, D.J. & Sherman, S.M. (1985). Projection patterns of individual X- and Y-cell axons from the lateral geniculate nucleus to cortical area 17 in the cat. Journal of Comparative Neurology 233, 159–189.CrossRefGoogle ScholarPubMed
Jagadeesh, B. & Ferster, D. (1988). X- and Y-like receptive-field properties in cat areas 17 and 18. Society for Neuroscience Abstracts 14, 899.Google Scholar
Koch, C., Douglas, R. & Wehmeier, U. (1990). Visibility of synaptically induced conductance changes: Theory and simulations of anatomically characterized cortical pyramidal cells. Journal of Neuroscience (in press).CrossRefGoogle Scholar
LeVay, S. & Ferster, D. (1977). Relay cell classes in the lateral geniculate nucleus and the effects of visual deprivation. Journal of Comparative Neurology 172, 563–584.CrossRefGoogle ScholarPubMed
Leventhal, A.G. (1979). Evidence that different classes of relay cells of the cat's lateral geniculate nucleus terminate in different layers of the striate cortex. Experimental Brain Research 37, 349–372.CrossRefGoogle ScholarPubMed
Leventhal, A.G. & Hirsch, H.V.B. (1978). Receptive-field properties of neurons of different laminae of visual cortex of the cat. Journal of Neurophysiology 41, 948–961.CrossRefGoogle ScholarPubMed
Lindström, S. & Wrobel, A. (1984). Separate inhibitory pathways to X and Y principal cells in the lateral geniculate nucleus of the cat. Neuroscience Letters (Suppl.) 18, 234S.Google Scholar
Martin, K.A.C. & Whitteridge, D. (1984). Form, function and intracortical projections of spiny neurones in the striate visual cortex of the cat. Journal of Physiology (London) 353, 463–504.CrossRefGoogle ScholarPubMed
Mitzdore, U. & Singer, W. (1977). Laminar segregation of afferents to lateral geniculate nucleus of the cat: an analysis of current source density. Journal of Neurophysiology 40, 1227–1244.CrossRefGoogle Scholar
Mitzdorf, U. & Singer, W. (1978). Prominent excitatory pathways in the cat visual cortex (A 17 and A 18): a current-source-density analysis of electrically evoked potentials. Experimental Brain Research 33, 371–394.CrossRefGoogle Scholar
Movshon, J.A., Thompson, I.D. & Tolhurst, D.J. (1978). Spatial and temporal contrast sensitivity of neurones in areas 17 and 18 of the cat's visual cortex. Journal of Physiology (London) 283, 101–120.CrossRefGoogle ScholarPubMed
Mullikan, W.H., Jones, J.P. & Palmer, L.A. (1984). Receptive-field properties and laminar distribution of X-like and Y-like simple cells in cat area 17. Journal of Neurophysiology 52, 350–371.CrossRefGoogle Scholar
Mustari, M.J., Bullier, J. & Henry, G.H. (1982). Comparison of response properties of three types of monosynaptic s-cell in cat striate cortex. Journal of Neurophysiology 47, 439–454.CrossRefGoogle ScholarPubMed
Palmer, L.A. & Davis, T.L. (1981). Receptive-field structure in cat striate cortex. Journal of Neurophysiology 46, 260–276.CrossRefGoogle ScholarPubMed
Rowe, M.H. & Stone, J. (1976). Conduction velocity groupings among axons of cat retinal ganglion cells, and their relationship to retinal topography. Experimental Brain Research 25, 339–357.CrossRefGoogle Scholar
Singer, W., Tretter, F. & Cynader, M. (1975). Organization of cat striate cortex: a correlation of receptive-field properties with afferent and efferent connections. Journal of Neurophysiology 38, 1080–1098.CrossRefGoogle ScholarPubMed
So, Y.T. & Shapley, R. (1979). Spatial properties of X and Y cells the lateral geniculate nucleus of the cat and conduction velocities of their inputs. Journal of Neurophysiology 36, 533–550.Google Scholar
Spitzer, H. & Hochstein, S. (1985). Simple-and complex-cell response dependences on stimulation parameters. Journal of Neurophysiology 53, 1244–1265.CrossRefGoogle ScholarPubMed
Tanaka, K. (1983 a). Cross-correlation analysis of geniculostriate neuronal relationships in cats. Journal of Neurophysiology 49, 1303–1318.CrossRefGoogle ScholarPubMed
Tanaka, K. (1983 b). Distinct X and Y streams in the cat visual cortex revealed by bicuculline application. Brain Research 265, 143–147.CrossRefGoogle ScholarPubMed
Thalluri, J. & Henry, G.H. (1989). Neurons of the striate cortex driven transsynaptically by electrical stimulation of the superior colliculus. Vision Research 29, 1319–1323.CrossRefGoogle ScholarPubMed
Tusa, R.J., Palmer, L.A. & Rosenquist, A.C. (1979 a). Retinotopic organization of area 17 (striate cortex) in the cat. Journal of Comparative Neurology 177, 213–236.CrossRefGoogle Scholar
Tusa, R.J., Palmer, L.A. & Rosenquist, A.C. (1979 b). Retinotopic organization of area 18 and 19 in the cat. Journal of Comparative Neurology 185, 657–678.CrossRefGoogle Scholar
Wilson, P.D., Rowe, M.H. & Stone, J. (1976). Properties of relay cells in the cat's lateral geniculate nucleus: a comparison of W cells with X and Y cells. Journal of Neurophysiology 39, 1193–1209.CrossRefGoogle ScholarPubMed