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Perspective: New genetic tools for studying retinal development and disease

Published online by Cambridge University Press:  06 December 2005

BRETT A. SCHWEERS  and
MICHAEL A. DYER
BRETT A. SCHWEERS
Affiliation:
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis
MICHAEL A. DYER
Affiliation:
Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis
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Abstract

The use of knock-out and transgenic mice has been instrumental for advancing our understanding of retinal development and disease. In this perspective, we review existing genetic approaches to studying retinal development and present a series of new genetic tools that complement the use of standard knock-out and transgenic mice. Particular emphasis is placed on elucidating cell-autonomous and non-cell-autonomous roles of genes important for retinal development and disease in vivo. In addition, a series of gene-swapping vectors can be used to elucidate the function of proteins that regulate key processes in retinal development and a wide variety of retinopathies.

Keywords

CompensationCell-autonomousRetrovirus
Type
Research Article
Information
Visual Neuroscience , Volume 22 , Issue 5 , September 2005 , pp. 553 - 560
Copyright
© 2005 Cambridge University Press

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