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Hierarchical decomposition of dichoptic multifocal visual evoked potentials

Published online by Cambridge University Press:  04 October 2006

TED MADDESS ,
ANDREW C. JAMES ,
RASA RUSECKAITE  and
ELIZABETH A. BOWMAN
TED MADDESS
Affiliation:
Centre for Visual Sciences and the ARC Centre of Excellence in Vision Science, Research School of Biological Sciences, Australian National University, Canberra, Australia
ANDREW C. JAMES
Affiliation:
Centre for Visual Sciences and the ARC Centre of Excellence in Vision Science, Research School of Biological Sciences, Australian National University, Canberra, Australia
RASA RUSECKAITE
Affiliation:
Centre for Visual Sciences and the ARC Centre of Excellence in Vision Science, Research School of Biological Sciences, Australian National University, Canberra, Australia
ELIZABETH A. BOWMAN
Affiliation:
Centre for Visual Sciences and the ARC Centre of Excellence in Vision Science, Research School of Biological Sciences, Australian National University, Canberra, Australia John Curtin School of Medical Research, Australian National University, Canberra, Australia
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Abstract

Visual evoked responses to dichoptically presented multifocal stimuli were recorded for 92 eyes. Two stimulus variants were explored: temporally sparse and rapidly contrast reversing. We used hierarchal decomposition (HD) to represent the multifocal responses in terms of a small number of potentially unique component waveforms that are interrelated in a multivariate linear autoregressive (MLAR) relationship. The HD method exploits temporal correlations over a range of delays in the responses to estimate parallel, feedforward and feedback relationships between the HD components. Three HD components having temporal interrelationships constrained (at P < 0.05) to a moving ∼20 ms window could describe the multifocal responses well (median r2-values up to 90%). HD components were similar for both stimulus types and the component waveforms were temporally correlated, especially the first and third components. The data set was large enough to estimate separate HD components for each multifocal stimulus region. The component waveforms differed somewhat by region but the MLAR relationships were similar. At short delays parallel processing dominated. At longer delays the proportion of response drives that were attributed to feedback and feedforward relationships grew. Overall HD analysis seems to provide an informed summary of multifocal responses and insights into their sources.

Keywords

MultifocalSparseVisual evoked potentialsmfVEPHierarchical decompositionPrincipal components
Type
Research Article
Information
Visual Neuroscience , Volume 23 , Issue 5 , September 2006 , pp. 703 - 712
Copyright
2006 Cambridge University Press

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