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Direction-selective responses of units in the dorsal terminal nucleus of cat following intravitreal injections of bicuculline

Published online by Cambridge University Press:  02 June 2009

K.L. Grasse ,
M. Ariel  and
I.D. Smith
K.L. Grasse
Affiliation:
Departments of Psychology and Biology, York University North York, Ontario, Canada B3JIP3
M. Ariel
Affiliation:
Department of Behavioural Neuroscience, University of Pittsburgh, Pittsburgh
I.D. Smith
Affiliation:
Department of Behavioural Neuroscience, University of Pittsburgh, Pittsburgh
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Abstract

Extracellular recordings from single units in the dorsal terminal nucleus (DTN) of the cat accessory optic system (AOS) were before and after intravitreal injections of the GABA antagonist bicuculline methiodide (BMI). Direction-selective responses of DTN cells elicited through the contralateral, injected eye were aboloshed 7−12 h following the injection. For the concentrations tested, direction-selective responses through the contralateral (injected) eye did not recover within 26 h. Direction-selective responses through stimulation of the ipsilateral (uninjected) eye were also dramatically depressed for 1−9 h after contralateral eye injections. However, direction-selective responses through the ipsilateral eye eventually returned and were often more vigorous in the final stages. BMI injections into the ipsilateral eye failed to block direction-selective responses through the ipsilateral eye. The effects of intravitreal BMI on contralateral eye responses imply that DTN units receive input from direction-selective retinal ganglion cells. In addition, these results suggest that direction-selective input to the DTN from the visual cortex is independent of the retinal pathway. Using pharmacological methods described here, for the first time direction-selective responses of AOS units driven through the ipsilateral eye can be experimentally isolated.

Keywords

Dorsal terminal nucleusAccessory optic systemDirection selectivityBicuculline methiodideBinocular interactionsCat
Type
Research Articles
Information
Visual Neuroscience , Volume 4 , Issue 6 , June 1990 , pp. 605 - 617
Copyright
Copyright © Cambridge University Press 1990

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