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Alternating monocular exposure increases the spacing of ocularity domains in area 17 of cats

Published online by Cambridge University Press:  02 June 2009

Suzannah Bliss Tieman  and
Nina Tumosa
Suzannah Bliss Tieman
Affiliation:
Neurobiology Research Center and Department of Biological Sciences, State University of New York, Albany
Nina Tumosa
Affiliation:
School of Optometry, University of Missouri-St. Louis, St. Louis
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Abstract

Goodhill (1993) has recently suggested that the spacing of ocularity domains in visual cortex is not solely an intrinsic property of cortex, but is determined, at least in part, by the degree of correlation in the activity of the two eyes. In support of this model, Löwel (1994) has shown that strabismus, which decorrelates the activity of the two eyes, increases the spacing of ocular dominance columns in area 17, but not area 18, of the cat. As a further test of Goodhill's model, in this paper we examine the effects of another rearing procedure that decorrelates the activity of the two eyes, namely alternating monocular exposure (AME). Cats were reared either normally (9 cats) or with AME (21 cats). We labeled their ocularity domains by one of three methods: ocular dominance columns by 2-deoxyglucose (14 cats), and ocular dominance patches by transneuronal transport (14 cats), or by injections of tracer into single layers of the lateral geniculate nucleus (LGN; 2 cats). The spacing of ocular dominance was 11% greater in the AME cats than in the normal cats (0.976 vs. 0.877 mm). These results are similar to those previously reported for strabismic cats, although the effect is less striking. We thus confirm that decorrelating the activity of the two eyes increases the spacing of cortical ocularity domains. Our results further suggest that the degree of decorrelation affects the extent of that increase.

Keywords

DevelopmentVisual cortexActivity-dependent regulationOcular dominance
Type
Research Articles
Information
Visual Neuroscience , Volume 14 , Issue 5 , September 1997 , pp. 929 - 938
Copyright
Copyright © Cambridge University Press 1997

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