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Use of Monozygotic Twins in Search for Breast Cancer Susceptibility Loci

Published online by Cambridge University Press:  21 February 2012

Asta Försti ,
Qianren Jin ,
Lena Sundqvist ,
Magnus Söderberg  and
Kari Hemminki
Asta Försti*
Affiliation:
Department of Biosciences at Novum, Karolinska Institute, Sweden. [email protected]
Qianren Jin
Affiliation:
Department of Biosciences at Novum, Karolinska Institute, Sweden.
Lena Sundqvist
Affiliation:
Department of Biosciences at Novum, Karolinska Institute, Sweden.
Magnus Söderberg
Affiliation:
Department of Pathology, Huddinge Hospital, Sweden.
Kari Hemminki
Affiliation:
Department of Biosciences at Novum, Karolinska Institute, Sweden.
*
*Address for correspondence: Asta Försti, Department of Biosciences at Novum, Karolinska Institute, SE-14157 Huddinge, Sweden.

Abstract

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We have used Swedish monozygotic twins concordant for breast cancer to study genetic changes associated with the development of breast cancer. Because loss of heterozygosity (LOH) at a specific genomic region may reflect the presence of a tumour suppressor gene, loss of the same allele in both of the twins concordant for breast cancer may pinpoint a tumour suppressor gene that confers a strong predisposition to breast cancer. DNA samples extracted from the matched tumour and normal tissues of nine twin pairs were analysed for allelic imbalance using a set of microsatellite markers on chromosomes 1, 13, 16 and 17, containing loci with known tumour suppressor genes. The two main regions, where more twin pairs than expected had lost the same allele, were located at 16qtel, including markers D16S393, D16S305 and D16S413, and at 17p13, distal to the p53 locus. Our results show that the monozygotic twin model can be used to suggest candidate regions of potential tumour suppressor genes, even with a limited number of twin pairs.

Type
Articles
Information
Twin Research and Human Genetics , Volume 4 , Issue 4 , 01 August 2001 , pp. 251 - 259
Copyright
Copyright © Cambridge University Press 2001