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The Tokyo Twin Cohort Project: Overview and Initial Findings

Published online by Cambridge University Press:  21 February 2012

Juko Ando ,
Koichi Nonaka ,
Koken Ozaki ,
Naho Sato ,
Keiko K. Fujisawa ,
Kunitake Suzuki ,
Shinji Yamagata ,
Yusuke Takahashi ,
Ryoko Nakajima  and
Noriko Kato
...Show all authors
Juko Ando*
Affiliation:
Faculty of Letters, Keio University, Minato-ku, Tokyo, Japan. [email protected]
Koichi Nonaka
Affiliation:
Faculty of Human Sciences, Wako University, Tokyo, Japan.
Koken Ozaki
Affiliation:
Japan Science and Technology Agency, Tokyo, Japan.
Naho Sato
Affiliation:
Japan Science and Technology Agency, Tokyo, Japan.
Keiko K. Fujisawa
Affiliation:
Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.
Kunitake Suzuki
Affiliation:
Faculty of Science, Tokyo Metropolitan University, Tokyo, Japan.
Shinji Yamagata
Affiliation:
Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.
Yusuke Takahashi
Affiliation:
Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan.
Ryoko Nakajima
Affiliation:
Graduate School of Human Relations, Keio University, Tokyo, Japan.
Noriko Kato
Affiliation:
National Institute of Public Health, Saitama, Japan.
Syuichi Ooki
Affiliation:
Ishikawa Prefectural Nursing University, Ishikawa, Japan.
*
*Address for correspondence: Juko Ando, Department Education, Faculty of Letters, Keio University, Tokyo, Japan.

Abstract

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The Tokyo Twin Cohort Project (ToTCoP) is a large-scale longitudinal study of 5 years based on 1619 pairs of infant twins reared together. The purpose of the study is to construct a population-based twin registry in Japan and to investigate human growth and development and twin themselves. It covers behavioral, neurological, physical and environmental variables measured by questionnaire, home visiting and brain imaging technology. The full registry contains over 47,000 multiple births collected from the Basic Resident Register, and the targeted population is 3070 probable twins of 0 to 2 years old. Preliminary analysis of the entry questionnaire data showed no serious sampling biases. Descriptive statistics of parental characteristics (parental age, gestation age, parity and placentation, maternal weight, parenting stress) and children's characteristics (body size at birth, 4 and 10 months of age, milk consumption, and sleeping and social behavior) and their correlations, genetic and environmental contributions and correlations are reported.

Type
Articles/Japan
Information
Twin Research and Human Genetics , Volume 9 , Issue 6 , 01 December 2006 , pp. 817 - 826
Copyright
Copyright © Cambridge University Press 2006