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Serum Inhibin A and B Concentrations During the Menstrual Cycle in Mothers of Spontaneous Dizygotic Twins

Published online by Cambridge University Press:  21 February 2012

Christopher P. Gilfillan ,
Grant W. Montgomery ,
Gu Zhu ,
Nicholas G. Martin ,
N. P. Groome  and
David M. Robertson
Christopher P. Gilfillan
Affiliation:
Prince Henry's Institute of Medical Research, Clayton,Victoria, Australia.
Grant W. Montgomery
Affiliation:
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland,Australia.
Gu Zhu
Affiliation:
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland,Australia.
Nicholas G. Martin
Affiliation:
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland,Australia.
N. P. Groome
Affiliation:
Oxford Brookes University, Oxford, UK.
David M. Robertson*
Affiliation:
Prince Henry's Institute of Medical Research, Clayton,Victoria, Australia. [email protected]
*
*Address for correspondence: Prof David Robertson, Prince Henry's Institute of Medical Research, Monash Medical Centre, 246 Clayton Road, Clayton Melbourne, VIC 3168, Australia.

Abstract

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Dizygotic twinning in humans is influenced by genetic factors suggesting inherited variation affects follicle development and predisposes to double ovulations. In a previous study, we conducted a detailed examination of follicle development and variation in hormone concentrations during the menstrual cycle in mothers of DZ twins (MODZT) compared with an age-matched control group of mothers of singletons. We did not detect differences in FSH concentrations between mothers of twins and mothers of singletons. Serum inhibin concentrations were measured by a radioimmunoassay that did not distinguish between dimeric inhibin A and B forms and free inhibin α subunit. We therefore analyzed the samples from this study with specific assays to determine whether concentrations of inhibin A and B were different between MODZT and controls and therefore contribute to the twinning phenotype. There were no significant differences between MODZT with single ovulations and control women in inhibin A and B concentrations during the cycle, including the critical period for the selection of the dominant follicle. These data suggest that the genetic cause of twinning is not associated with changes in FSH concentrations or recognised feedback mechanisms regulating FSH release.

Type
Articles
Information
Twin Research and Human Genetics , Volume 6 , Issue 1 , 01 February 2003 , pp. 27 - 33
Copyright
Copyright © Cambridge University Press 2003