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Parameterization of Sex-Limited Autosomal Linkage Analysis for Mx

Published online by Cambridge University Press:  21 February 2012

Sarah E. Medland
Sarah E. Medland*
Affiliation:
Queensland Institute of Medical Research, Brisbane, Australia; Cognitive Psychophysiology Laboratory, University of Queensland, Australia. [email protected]
*
*Address for correspondence: Sarah Medland, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane 4029, Australia.

Abstract

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Incorporation of sex-limitation (genotype-sex interaction) effects into a model of quantitative trait loci (QTL) analysis has been shown to increase the power to detect linkage when analyzing traits in which sex limitation is present (Towne et al., 1997). The present note provides a parameterization of the nonscalar sex-limitation ACE model incorporating autosomal sex-limited QTL effects for use with the Mx matrix algebra program (Neale et al., 2002). An example script designed for use with extended sib- ships that takes advantage of the versatile treatment of covariates within Mx is included.

Type
Articles
Information
Twin Research and Human Genetics , Volume 8 , Issue 6 , 01 December 2005 , pp. 569 - 573
Copyright
Copyright © Cambridge University Press 2005