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Insulin-Like Growth Factor-1 Levels in Twins and Its Correlation With Discordance

Published online by Cambridge University Press:  21 February 2012

Fuat Emre Canpolat ,
Ferhat Çekmez ,
Serdar Ümit Sarici ,
Ayşe Korkmaz  and
Murat Yurdakok
Fuat Emre Canpolat*
Affiliation:
Hacettepe University Faculty of Medicine, Department of Pediatrics, Ankara, Turkey. [email protected]
Ferhat Çekmez
Affiliation:
Department of Pediatrics, Gulhane Military Academy of Medicine, Ankara, Turkey.
Serdar Ümit Sarici
Affiliation:
Department of Pediatrics, Gulhane Military Academy of Medicine, Ankara, Turkey.
Ayşe Korkmaz
Affiliation:
Hacettepe University Faculty of Medicine, Department of Pediatrics, Ankara, Turkey.
Murat Yurdakok
Affiliation:
Hacettepe University Faculty of Medicine, Department of Pediatrics, Ankara, Turkey.
*
*Address for correspondence: Fuat Emre Canpolat, M.D., Harbiye Mahallesi, Salkim Söğüt Sokak 18-9, 06460 Dikmen Çankaya, Ankara TURKEY.

Abstract

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This study aims to determine whether fetal growth is related to insulin-like growth factor-1 in dichorionic and monochorionic twins and also aims to investigate the correlation of insulin-like growth factor-1 to birthweight discordance in twins. We studied 100 women with twin pregnancies. The correlation tests of 36 discordant twins (15 monochorionic, 21 dichorionic) showed correlation between insulin-like growth factor-1 difference and birthweight discordance (insulin-like growth factor-1 vs. birthweight of first twin, r = +0.915, at 0.01 level, IGF-1 vs birthweight of second twin r = +0.790, at 0.01 level). In 49 monochorionic twins, independent of discordance, there was a correlation between birthweight discordance and insulin-like growth factor-1 difference (r = .538, at the 0.01 level). This correlation was not significant in dichorionic twins, r = .144, p = .01. These data suggest that growth discordances of twins exposed to the same maternal environment may be due to variations in IGF-1, depending upon the genetic similarity.

Keywords

IGF-1discordancetwinfetal growth
Type
Articles
Information
Twin Research and Human Genetics , Volume 14 , Issue 1 , 01 February 2011 , pp. 94 - 97
Copyright
Copyright © Cambridge University Press 2011