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Influence of Gestational Diabetes Mellitus on Weight Discrepancy in Twin Pregnancies

Published online by Cambridge University Press:  21 February 2012

Katharina Klein ,
Mariella Mailath-Pokorny ,
Heinz Leipold ,
Elisabeth Krampl-Bettelheim  and
Christof Worda
Katharina Klein*
Affiliation:
Department of Obstetrics and Gynecology, Medical University of Vienna, Austria. [email protected]
Mariella Mailath-Pokorny
Affiliation:
Department of Obstetrics and Gynecology, Medical University of Vienna, Austria.
Heinz Leipold
Affiliation:
Department of Obstetrics and Gynecology, General Hospital of Klagenfurt, Austria.
Elisabeth Krampl-Bettelheim
Affiliation:
Department of Obstetrics and Gynecology, Medical University of Vienna, Austria.
Christof Worda
Affiliation:
Department of Obstetrics and Gynecology, Medical University of Vienna, Austria.
*
*Address for correspondence: Katharina Klein, MD, Department of Obstetrics and Gynecology, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Australia.

Abstract

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Objective: To evaluate the influence of gestational diabetes mellitus on weight discrepancy in twin pregnancies. Methods: 200 twin pregnancies were included in the study. 157 nondiabetic pregnant women with twin gestations and 43 twin pregnancies with gestational diabetes mellitus (GDM) with viable fetuses born after 24 weeks of gestation were enrolled. Influence of maternal age, body-mass-index at the time of the oral glucose tolerance test, parity, smoking, chorionicity, gestational age at delivery and diagnosis of GDM on weight discrepancy of the twins was evaluated. Results: Mean weight discrepancy of all analyzed twin pregnancies was 285 grams (± 231), relative weight discrepancy was 11.3% (± 8.6). Univariate regression analyses showed that GDM, chorionicity and gestational age at delivery were significantly associated with weight discrepancy. In the multivariate model only diagnosis of GDM was significantly associated with weight discrepancy. Conclusion: Twin pregnancies with insulin requiring gestational diabetes seem to have less birth weight discrepancy than twin pregnancies with normal glucose tolerance.

Keywords

twin pregnancygestational diabetes mellitusweight discrepancy
Type
Articles
Information
Twin Research and Human Genetics , Volume 13 , Issue 4 , 01 August 2010 , pp. 393 - 397
Copyright
Copyright © Cambridge University Press 2010