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Hypotheses on the Effect of Cadmium on Glutathione Content of Red Blood Corpuscles

Published online by Cambridge University Press:  21 February 2012

Sri Niranjan Shekar ,
Tathagata Banerjee  and
Atanu Biswas
Sri Niranjan Shekar*
Affiliation:
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia. [email protected]
Tathagata Banerjee
Affiliation:
Indian Institute of Management Ahmedabad, Vastrapur, Ahmedabad, India.
Atanu Biswas
Affiliation:
Atanu Biswas, Applied Statistics Unit, Indian Statistical Institute, Kolkata, India.
*
*Address for correspondence: Sri Niranjan Shekar, Genetic Epidemiology Unit, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane 4029, Australia.

Abstract

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Previous studies have shown that Glutathione, a tripeptide found in blood, is involved in protecting against toxins. Glutathione levels are known to drop in response to cadmium. Using 15 twin pairs, we modeled the effect of cadmium on glutathione levels. The heritability of glutathione content was 91%. The application of cadmium significantly reduced the mean level of GSH. However, this reduction in GSH was not due to additive genetic influences in our sample.

Type
Articles
Information
Twin Research and Human Genetics , Volume 9 , Issue 1 , 01 February 2006 , pp. 73 - 75
Copyright
Copyright © Cambridge University Press 2006