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The Heritability of Premenstrual Syndrome

Published online by Cambridge University Press:  21 February 2012

Shayesteh Jahanfar
Affiliation:
School of Population and Public Health, University of British Columbia, Vancouver, Canada.
Munn-Sann Lye*
Affiliation:
Faculty of Medicine and Health Sciences, University Putra Malaysia, Selangor, Malaysia. [email protected]
Isthrinayagy S. Krishnarajah
Affiliation:
Faculty of Science, University Putra Malaysia, Selangor, Malaysia.
*
*ADDRESS FOR CORRESPONDENCE: Munn-Sann Lye, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia.

Abstract

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We aimed to determine (1) the prevalence of premenstrual syndrome in a sample of twins and (2) the relative contribution of genes and environment in premenstrual syndrome. A group of 193 subjects inclusive of same gender twins (n = 176) and females from opposite sex twin sets (n = 17) entered the study. Heritability analysis used same gender twin data only. The probandwise concordance rate for the presence or absence of premenstrual syndrome was calculated and the heritability of premenstrual syndrome was assessed by a quantitative genetic model fitting approach using MX software. The prevalence of premenstrual syndrome was 43.0% and 46.8% in monozygotic and dizygotic twins, respectively. The probandwise concordance for premenstrual syndrome was higher in monozygotic (0.81) than in dizygotic twins (0.67), indicating a strong genetic effect. Quantitative genetic modeling found that a model comprising of additive genetic (A) and unique environment (E) factors provided the best fit (A: 95%, E: 5%). No association was found between premenstrual symptom and the following variables: belonging to the opposite gender twin set, birth weight, being breast fed and vaccination. These results established a clear genetic influence in premenstrual syndrome.

Type
Articles
Copyright
Copyright © Cambridge University Press 2011