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Genetic and Environmental Influences on Adiponectin, Leptin, and BMI Among Adolescents in Taiwan: A Multivariate Twin/Sibling Analysis

Published online by Cambridge University Press:  21 February 2012

Pi-Hua Liu ,
Yi-Der Jiang ,
Wei J. Chen ,
Ching-Chung Chang ,
Tso-Ching Lee ,
H. Sunny Sun  and
Lee-Ming Chuang
Pi-Hua Liu
Affiliation:
Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan; Genetic Epidemiology Core Laboratory, Research Center for Medical Excellence, National Taiwan University, Taipei, Taiwan.
Yi-Der Jiang
Affiliation:
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Wei J. Chen
Affiliation:
Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan; Genetic Epidemiology Core Laboratory, Research Center for Medical Excellence, National Taiwan University, Taipei, Taiwan.
Ching-Chung Chang
Affiliation:
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Tso-Ching Lee
Affiliation:
Department of Medical Research and Education, Taichung Veterans General Hospital, Taichung, Taiwan.
H. Sunny Sun
Affiliation:
Institute of Molecular Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Lee-Ming Chuang*
Affiliation:
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan. [email protected]
*
*Address for correspondence: Lee-Ming Chuang, MD, PhD, Department of Internal Medicine, National Taiwan University Hospital, 7 Chung-Shan South Road, Taipei, Taiwan.

Abstract

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Circulating levels of leptin and adiponectin are closely associated with obesity. However, it is not known whether there are common shared genes or environment exerting influences on the levels of leptin, adiponectin, and BMI. We aimed to assess the relative contribution of genes and environment to adiponectin, leptin, and BMI individually as well as simultaneously to the three measures. Our subjects included a total of 228 twin/sibling pairs aged 12 to 18 (130 monozygotic twins, 68 dizygotic twins and 30 sibling pairs) were recruited from the middle schools. Multivariate analyses were applied to twin/sibling data using structural equation modeling. The results showed that intraclass correlations for adiponectin, leptin and BMI were higher in the MZ twins than those in the DZ/SP group. The relative contribution of genes to adiponectin (39%) was comparable to those of shared environment (40%). In contrast, leptin and BMI were influenced mostly by genes (74% and 89%, respectively). The multivariate genetic analyses showed that a latent factor underlying the three measures was identified, with BMI being equivalent to this latent factor. The BMI-dependent genetic factor explains only 15% and 34% of variation of adiponectin and leptin, respectively. These data indicate a differential contribution of genetic factors for the variation of adiponectin, leptin and BMI. More importantly, only a small portion of the genetic influences on adiponectin and leptin was attributed to BMI. Our findings provided more insight into the complex regulation of adiponectin and leptin in obesity.

Keywords

adiponectinleptinBMItwins
Type
Articles
Information
Twin Research and Human Genetics , Volume 11 , Issue 5 , 01 October 2008 , pp. 495 - 504
Copyright
Copyright © Cambridge University Press 2008