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The effect of apolipoprotein(a)-, apolipoprotein E-, and apolipoprotein A4- polymorphisms on quantitative lipoprotein(a) concentrations

Published online by Cambridge University Press:  21 February 2012

DI Boomsma ,
P de Knijff ,
A Kaptein ,
C Labeur ,
NG Martin ,
LM Havekes  and
HMG Princen
DI Boomsma*
Affiliation:
Vrije Universiteit, [email protected]
P de Knijff
Affiliation:
MGC, Department of Human Genetics, Sylvius Laboratory, Leiden
A Kaptein
Affiliation:
Gaubius Laboratory, TNO/PG, Leiden, The Netherlands
C Labeur
Affiliation:
AZ St-Jan, Brugge, Belgium
NG Martin
Affiliation:
Queensland Institute of Medical Research, Brisbane, Australia
LM Havekes
Affiliation:
Gaubius Laboratory, TNO/PG, Leiden, The Netherlands
HMG Princen
Affiliation:
Gaubius Laboratory, TNO/PG, Leiden, The Netherlands
*
*Correspondence: DI Boomsma, Vrije Universiteit, De Boelelaan 1111, 1081 HV Amsterdam, The Netherlands. Tel: 31 20 444 8789/8787; Fax: 31 20 444 8832

Abstract

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The effects of apolipoprotein (a), apolipoprotein-E, and apolipoprotein-A4 isoforms on quantitative lipoprotein(a) [Lp(a)] levels were assessed in a sample of 142 Dutch families consisting of two parents and their adolescent twin offspring. A total heritability of 95% was estimated for plasma Lp(a) concentrations. The largest part of this heritability was due to the apo(a) locus which explained 61% of the total variance in Lp(a) levels. The pattern of familial correlations for the residual part of the Lp(a) variance that could not be attributed to the apo(a) isoforms, suggested genetic influences on the residual variance. We addressed the question whether this residual genetic variance could be ascribed to the apoE or the apoA4 locus. A simultaneous analysis of all three loci showed that both the apoE and the apoA4 polymorphism did not contribute significantly to Lp(a) variation. Twin Research (2000) 3, 152–158.

Keywords

familial resemblanceheritabilitytwinsparent–offspringApo(a)ApoEApoA4lipoprotein(a) [Lp(a)] concentrations
Type
Articles
Information
Twin Research and Human Genetics , Volume 3 , Issue 3 , 01 June 2000 , pp. 152 - 158
Copyright
Copyright © Cambridge University Press 2000