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Course of Ovarian Hyperstimulation Syndrome in 19 Intact Twin Pregnancies After Assisted Reproduction Techniques, With a Case Report of Severe Thromboembolism

Published online by Cambridge University Press:  21 February 2012

Susanne Cupisti ,
Jasmin Emran ,
Andreas Mueller ,
Ralf Dittrich ,
Matthias W. Beckmann  and
Helge Binder
Susanne Cupisti*
Affiliation:
Department of Obstetrics and Gynecology, University Hospital, Erlangen, Germany. [email protected]
Jasmin Emran
Affiliation:
Department of Obstetrics and Gynecology, University Hospital, Erlangen, Germany.
Andreas Mueller
Affiliation:
Department of Obstetrics and Gynecology, University Hospital, Erlangen, Germany.
Ralf Dittrich
Affiliation:
Department of Obstetrics and Gynecology, University Hospital, Erlangen, Germany.
Matthias W. Beckmann
Affiliation:
Department of Obstetrics and Gynecology, University Hospital, Erlangen, Germany.
Helge Binder
Affiliation:
Department of Obstetrics and Gynecology, University Hospital, Erlangen, Germany.
*
*Address for correspondence: Dr Susanne Cupisti, Department of Obstetrics and Gynecology, Erlangen University Hospital, Universitätsstrasse 21–23, D-91054 Erlangen, Germany.

Abstract

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Ovarian hyperstimulation syndrome (OHSS) is a serious complication of assisted reproduction techniques using in vitro fertilization and intracytoplasmic sperm injection (IVF/ICSI). Its etiology has still not yet been fully resolved. Human chorionic gonadotrophin, administered exogenously as well as produced endogenously during pregnancy, is responsible for the onset of OHSS, and high levels of estradiol appear to worsen the condition. In this case series, the course of mild to severe OHSS was evaluated in 19 intact twin pregnancies after IVF/ICSI. Another serious complication associated with OHSS is thromboembolic events. In these cases, the pregnancy can be protected through anticoagulation treatment, but there may be exceptions to this. This series includes a case of bilateral thrombosis of the internal and external jugular veins in the 7th gestational week in a twin pregnancy after OHSS and ICSI, with termination of the pregnancy in the 9th gestational week due to progressive thrombosis during anticoagulation therapy.

Type
Articles
Information
Twin Research and Human Genetics , Volume 9 , Issue 5 , 01 October 2006 , pp. 691 - 696
Copyright
Copyright © Cambridge University Press 2006