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Automatic network reconstruction using ASP

Published online by Cambridge University Press:  06 July 2011

MARKUS DURZINSKY ,
WOLFGANG MARWAN ,
MAX OSTROWSKI ,
TORSTEN SCHAUB  and
ANNEGRET WAGLER
MARKUS DURZINSKY
Affiliation:
Magdeburg Centre for Systems Biology, Universität Magdeburg, Germany
WOLFGANG MARWAN
Affiliation:
Magdeburg Centre for Systems Biology, Universität Magdeburg, Germany
MAX OSTROWSKI
Affiliation:
Universität Potsdam, Germany
TORSTEN SCHAUB
Affiliation:
Universität Potsdam, Germany
ANNEGRET WAGLER
Affiliation:
Université Blaise Pascal, Clermont-Ferrand, France
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Abstract

Building biological models by inferring functional dependencies from experimental data is an important issue in Molecular Biology. To relieve the biologist from this traditionally manual process, various approaches have been proposed to increase the degree of automation. However, available approaches often yield a single model only, rely on specific assumptions, and/or use dedicated, heuristic algorithms that are intolerant to changing circumstances or requirements in the view of the rapid progress made in Biotechnology. Our aim is to provide a declarative solution to the problem by appeal to Answer Set Programming (ASP) overcoming these difficulties. We build upon an existing approach to Automatic Network Reconstruction proposed by part of the authors. This approach has firm mathematical foundations and is well suited for ASP due to its combinatorial flavor providing a characterization of all models explaining a set of experiments. The usage of ASP has several benefits over the existing heuristic algorithms. First, it is declarative and thus transparent for biological experts. Second, it is elaboration tolerant and thus allows for an easy exploration and incorporation of biological constraints. Third, it allows for exploring the entire space of possible models. Finally, our approach offers an excellent performance, matching existing, special-purpose systems.

Type
Regular Papers
Information
Theory and Practice of Logic Programming , Volume 11 , Special Issue 4-5: 27th International Conference on Logic Programming , July 2011 , pp. 749 - 766
Copyright
Copyright © Cambridge University Press 2011

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