Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-27T21:33:49.244Z Has data issue: false hasContentIssue false
  • English
  • Français

Who Responds to Prophylactic Lithium Therapy?

Published online by Cambridge University Press:  06 August 2018

M. T. Abou-Saleh
M. T. Abou-Saleh*
Affiliation:
Department of Psychiatry and Behavioural Science, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates
Get access Rights & Permissions [Opens in a new window]

Abstract

The search for predictors of outcome has not been particularly rewarding, and the use of lithium remains empirical: a trial of lithium is the most powerful predictor of outcome. However, lithium is a highly specific treatment for bipolar disorder. In non-bipolar affective disorder, factors of interest are correlates of bipolar disorder: mood-congruent psychotic features, retarded-endogenous profile, cyclothymic personality, positive family history of bipolar illness, periodicity, and normality between episodes of illness.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 163 , Issue S21: Prediction in Psychopharmacology , September 1993 , pp. 20 - 26
Copyright
Copyright © 1993 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Aagaard, J. & Vestergaard, P. (1990) Predictors of outcome in prophylactic lithium treatment: a 2-year prospective study. Journal of Affective Disorders, 18, 259–266.Google Scholar
Abou-Saleh, M. T. (1980) Prediction of lithium response in manic-depressive illness. MPhil thesis, University of Edinburgh (unpublished).Google Scholar
Abou-Saleh, M. T. (1983) Platelet MAO, personality and response to lithium prophylaxis. Journal of Affective Disorders, 5, 55–65.Google Scholar
Abou-Saleh, M. T. & Coppen, A. J. (1986) Who responds to prophylactic lithium? Journal of Affective Disorders, 10, 115–125.Google Scholar
Abou-Saleh, M. T. & Coppen, A. J. (1989) The efficacy of low-dose lithium: clinical, psychological and biological correlates. Journal of Psychiatric Research, 23, 157–162.CrossRefGoogle ScholarPubMed
Abou-Saleh, M. T. & Coppen, A. J. (1990) Predictors of long-term outcome of mood disorder on prophylactic lithium. Lithium, 1, 27–35.Google Scholar
Abou-Saleh, M. T., Swade, C. & Coppen, A. J. (1992) Increased platelet 5-HT transport is associated with decreased morbidity during lithium prophylaxis, Lithium, 3, 301–304.Google Scholar
Ahlfors, U. G., Baastrup, P. C., Dencker, S. J., et al (1981) Flupenthixol decanoate in recurrent manic-depressive illness: a comparison with lithium. Acta Psychiatrica Scandinavica, 64, 226–237.Google Scholar
Ananth, J., Ghadirian, A. M. & Engelsmann, F. (1979) Prediction of lithium response. Acta Psychiatrica Scandinavica, 60, 279–286.Google Scholar
Angst, J. (1981) Clinical indications for a prophylactic treatment of depression. Advances in Biological Psychiatry, 7, 218–229.Google Scholar
Burdick, B. M. & Holmes, C. B. (1980) Use of the lithium response scale with an out-patient psychiatric sample. Psychological Reports, 47, 69–70.Google Scholar
Carroll, B. J. (1979) Prediction of treatment outcome with lithium. Archives of General Psychiatry, 36, 870–878.Google Scholar
Coppen, A. & Abou-Saleh, M. T. (1983) Lithium in the prophylaxis of unipolar depression: a review. Journal of the Royal Society of Medicine, 76, 297–301.Google Scholar
Coppen, A., Abou-Saleh, M. T., Milln, P., et al (1983) Decreasing lithium dosage reduces morbidity and side-effects during prophylaxis. Journal of Affective Disorders, 5, 353–362.CrossRefGoogle ScholarPubMed
Coppen, A. & Swade, C. (1986) Reduced lithium dosage improves prophylaxis: a possible mechanism. In Depressive Illness: Prediction of Course and Outcome (eds Hippius, H., Klerman, G. L. & Matussek, N.), pp. 126–130. Berlin: Springer-Verlag.Google Scholar
Coppen, A. & Abou-Saleh, M. T. (1988) Lithium therapy: from clinical trials to practical management. Acta Psychiatrica Scandinavica, 78, 744–762.Google Scholar
Coppen, A., Standish-Barry, H., Bailey, J., et al (1991) Does lithium reduce the mortality of recurrent mood disorders? Journal of Affective Disorders, 23, 1–7 CrossRefGoogle ScholarPubMed
Dickson, W. E. & Kendell, R. E. (1986) Does maintenance lithium therapy prevent recurrences of mania under ordinary clinical conditions? Psychological Medicine, 16, 521–530.Google Scholar
Dunner, D. L. & Fieve, R. R. (1974) Clinical factors in lithium carbonate prophylaxis failure. Archives of General Psychiatry, 30, 229–233.Google Scholar
Dunner, D. L., Fleiss, J. L. & Fieve, R. R. (1976) Lithium carbonate prophylaxis failure. British Journal of Psychiatry, 129, 40–44.Google Scholar
Dunner, D. L., Stallone, F. & Fieve, R. R. (1982) Prophylaxis with lithium carbonate: an update. Archives of General Psychiatry, 39, 1344–1345.Google Scholar
Extein, I., Pottash, A. C. & Gold, M. S. (1985) Thyroid tests as predictors of treatment response and prognosis in psychiatry. Psychiatric Hospital, 16, 127–130.Google Scholar
Fieve, R. R. & Peselow, E. D. (1983) Lithium: clinical applications. In Antidepressants (eds G. D. Burrows, T. R. Normal & B. Cavies), pp. 277–321. Amsterdam: Elsevier.Google Scholar
Gelenberg, A. J., Kane, J. M. & Keller, M. B. (1989) Comparison of standard and low serum levels of lithium for maintenance treatment of bipolar disorders. New England Journal of Medicine, 321, 1489–1493.Google Scholar
Glen, A. M. I., Johnson, A. L. & Shepherd, M. (1981) Continuation therapy with lithium and amitriptyline in unipolar depressive illness: a controlled clinical trial. Psychological Medicine, 11, 409–416.Google Scholar
Goodwin, F. K. & Jamison, K. R. (eds) (1990a) Maintenance medical treatment. In Manic-Depressive Illness, pp. 665–724. Oxford: Oxford University Press.Google Scholar
Goodwin, F. K. & Jamison, K. R. (eds) (1990b) Course and outcome. In Manic-Depressive Illness, pp. 127–156. Oxford: Oxford University Press.Google Scholar
Grof, E., Haag, M., Grof, P., et al (1987) Lithium response and the sequence of episode polarities: preliminary report on a Hamilton sample. Progress in Neuropsychopharmacology and Biological Psychiatry, 11, 199–203.Google Scholar
Guze, S. B. & Robins, E. (1970) Suicide and primary affective disorders. British Journal of Psychiatry, 117, 437–438.Google Scholar
Haag, H., Heidorn, A., Haag, M., et al (1987) Sequence of affective polarity and lithium response: preliminary report on the Munich sample. Progress in Neuropsychopharmacology and Biological Psychiatry, 11, 205–208.Google Scholar
Hall, K. S., Dunner, D. L., Zeller, G., et al (1977) Bipolar illness: a prospective study of life events. Comprehensive Psychiatry, 18, 497–502.Google Scholar
Jerram, T. C. & McDonald, R. (1978) Plasma lithium control, with particular reference to minimum effective levels. In Lithium in Medical Practice (eds F. N. Johnson & S. Johnson), pp. 407–413. Lancaster: MTP Press.Google Scholar
Kane, J. M., Quitkin, F. M., Rifkin, A., et al (1982) Lithium carbonate and imipramine in the prophylaxis of unipolar and bipolar II illness: a prospective, placebo-controlled comparison. Archives of General Psychiatry, 39, 1065–1069.Google Scholar
Kerry, R. J. & Orme, J. E. (1979) Lithium, manic-depressive illness and psychological test performance. British Medical Journal, i, 230.Google Scholar
Kiloh, L. G., Andrews, G. & Neilson, M. (1988) The long-term outcome of depressive illness. British Journal of Psychiatry, 153, 752–757.Google Scholar
Kukopulos, A., Reginaldi, D., Laddomada, P., et al (1980) Course of the manic-depressive cycle and changes caused by treatments. Pharmacopsychiatry and Neuropsychopharmacology, 13, 156–167.CrossRefGoogle Scholar
Kupfer, D. J., Pickar, D. & Himmelhoch, J. M. (1975) Are there two types of unipolar depression? Archives of General Psychiatry, 32, 866–871.Google Scholar
Lancet (1992) Depression and suicide: are they preventable? Lancet, 340, 700–701.CrossRefGoogle Scholar
Lee, A. S. & Murray, R. M. (1988) The long-term outcome of Maudsley depressives. British Journal of Psychiatry, 153, 741–751.Google Scholar
Maj, M., DelVecchio, M., Starace, F., et al (1984) Prediction of affective psychoses response to lithium prophylaxis - the role of sociodemographic clinical, psychological and biological variables. Acta Psychiatrica Scandinavica, 69, 37–44.Google Scholar
Mendlewicz, J. (1979) Prediction of treatment outcome: family and twin studies in lithium prophylaxis and the question of lithium red blood cell/plasma ratio. In Lithium Controversies and Unresolved Issues (eds T. B. Cooper et al). Amsterdam: Excerpta Medica.Google Scholar
Mendlewicz, J., Fieve, R. R. & Stallone, F. (1973) Relationship between the effectiveness of lithium therapy and family history. American Journal of Psychiatry, 130, 1011–1031.Google Scholar
Mendlewicz, J., Verbanck, S. & Linkowski, P. (1978) Lithium accumulation in erythrocytes of manic-depressive patients: an in vivo twin study. British Journal of Psychiatry, 133, 436–444.Google ScholarPubMed
Milln, P. T. S. & Patch, C. (1988) Lithium dose reduction trial. In Lithium: Inorganic Pharmacology and Psychiatric Use (ed. Birch, N. J.), pp. 33–34. Oxford, Washington DC: IRL Press.Google Scholar
Misra, P. C. & Burns, B. H. (1977) Lithium non-responders in a lithium clinic. Acta Psychiatrica Scandinavica, 55, 32–40.Google Scholar
Norton, B. & Whalley, L. J. (1984) Mortality of a lithium-treated population. British Journal of Psychiatry, 145, 277–282.Google Scholar
O'Connell, R. A., Mayo, J. A., Eng, L. K., et al (1985) Social support and long-term lithium outcome. British Journal of Psychiatry, 147, 212–215.CrossRefGoogle ScholarPubMed
Peselow, E. D., Dunner, D. L., Fieve, R. R., et al (1982). Lithium prophylaxis of depression in unipolar, bipolar II, and cyclothymic patients. American Journal of Psychiatry, 139, 747–752.Google Scholar
Peselow, E. D., Dunner, D. L., Fieve, R. R. (1990) Psychopharmacology in clinical practice: the prophylaxis of unipolar depression. Lithium, 1, 115–123.Google Scholar
Priebe, S., Wildgrube, C. & Muller-Oerlinghausen, B. (1989) Lithium prophylaxis and expressed emotions. British Journal of Psychiatry, 154, 396–399.Google Scholar
Prien, R. F., Caffey, F. M. & Klett, C. J. (1974) Factors associated with treatment success in lithium carbonate prophylaxis. Archives of General Psychiatry, 31, 189–192.Google Scholar
Prien, R. F., Kupfer, D. J., Mansky, P. A., et al (1984) Drug therapy in the prevention of recurrences in unipolar and bipolar affective disorders. Archives of General Psychiatry, 41, 1096–1104.Google Scholar
Schou, M. (1979) Lithium as a prophylactic agent in unipolar affective illness: comparison with cyclic antidepressants. Archives of General Psychiatry, 36, 849–851.Google Scholar
Shopsin, B. & Waters, B. (1980) The pharmacotherapy of major depressive syndrome: Part 2. Prophylaxis of recurrent depressive illness. Psychosomatics, 21, 649–656.CrossRefGoogle ScholarPubMed
Stallone, F., Shelley, F. & Mendlewicz, J. (1973) The use of lithium in affective disorders: III. A double-blind study of prophylaxis in bipolar illness. American Journal of Psychiatry, 130, 1006–1010.Google Scholar
Stancer, H. C., Furlong, F. E. & Godse, D. D. (1970) A longitudinal investigation of lithium as a prophylactic agent for recurrent depression. Canadian Psychiatric Association Journal, 15, 29–40.CrossRefGoogle Scholar
Steinbrook, R. M. & Chapman, A. B. (1979) Lithium responders: an evaluation of psychological test characteristics. Comprehensive Psychiatry, 11, 524–530.CrossRefGoogle Scholar
Svestka, J. & Náhunek, K. (1975) The result of lithium therapy in acute phases of affective psychoses and some other prognosticator factors of lithium prophylaxis. Activitas Nervosa Superior, 17, 270–272.Google Scholar
Waters, B., Lapierre, Y. D., Gagnon, A., et al (1982) Determination of the optimal concentration of lithium for the prophylaxis of manic-depressive disorder. Biological Psychiatry, 17, 1323–1329.Google ScholarPubMed
WHO Mental Health Collaborating Centres (1989) Pharmacotherapy of depressive disorders: a consensus statement. Journal of Affective Disorders, 17, 197–198.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.