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Urinary 17-Ketosteroid Fractionation in Depression: a Preliminary Report

Published online by Cambridge University Press:  29 January 2018

J. Mendels
J. Mendels*
Affiliation:
Affective Diseases Research Unit, Department of Psychiatry, University of Pennsylvania and Veterans Administration Hospital, University and Woodland Avenues, Philadelphia, Pennsylvania 19104
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Extract

Most of the studies of steroid metabolism in depression conducted thus far have been of glucocorticoid activity. Rubin and Mandell (31) reviewed adrenal cortisol production in pathological emotional states and concluded that there was ample evidence of heightened cortical release of 17-hydroxycorticoids (17 OHGS) in depression.

Type
Biochemical Studies
Information
The British Journal of Psychiatry , Volume 115 , Issue 522 , May 1969 , pp. 581 - 585
Copyright
Copyright © Royal College of Psychiatrists, 1969 

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References

1 Aurell, M., Cramer, K., and Rybo, G. (1966). “Serum lipids and lipo-proteins during long-term administration of an oral contraceptive.” Lancet, i, 291–293.CrossRefGoogle Scholar
2 Batt, J. C. (1961). “Review of endocrinological investigations at St. Ebba's Hospital.” Proceedings, Third World Congress of Psychiatry. Montreal: McGill University Press.Google Scholar
3 Beck, A. T., Ward, C. H., Mendelson, M., Mock, J., and Erbaugh, J. (1961). “An inventory for measuring depression.” Arch. gen. Psychiat. (Chic.), 4, 561–571.Google Scholar
4 Board, F. A., Wadeson, R., and Persky, H. (1951). “Depressive affect and endocrine functions.” Arch. Neurol. Psychiat. (Chic.), 78, 612–620.Google Scholar
5 Brooks, R. V. (1958). “A method for the quantitative fractionation of urinary 17-oxy steroids with some observations on steroid excretion during administration of ACTH and in the andrenogenital syndrome.” Biochem. J., 68, 50–57.Google Scholar
6 Brooks, R. V. and Prunty, F. T. G. (1960). “Patterns of steroid excretion in three types of post-pubertal hirsutism.” J. Endocrinol., 21, 263–276.CrossRefGoogle Scholar
7 Brooksbank, B. W. L., and Haslewood, G. A. D. (1961). “The estimation of androst-16-en-3-01 in human urine.” Biochem. J., 80, 488–496.CrossRefGoogle Scholar
8 Brooksbank, B. W. L., and Haslewood, G. A. D. (1962). “Urinary steroids and mental illness.” Lancet, ii, 150–151.Google Scholar
9 Brooksbank, B. W. L., and Haslewood, G. A. D. (1962). “Urinary excretion of androst-16-en-3-01 levels in normal subjects, and the effects of treatment with trophic hormones.” J. Endocrinol., 24, 435–444.Google Scholar
10 Bush, I. E., and Mahesh, V. B. (1959). “Adrenocortical hyperfunction with sudden onset of hirsutism.” Ibid., 18, 1–25.Google Scholar
11 Daly, R. J., Kane, F. J., and Ewing, J. A. (1967). “Psychosis associated with the use of a sequential oral contraceptive.” Lancet, ii, 444–445.CrossRefGoogle Scholar
12 Davis, J., Morrill, R., Fawcett, J., Upton, V., Bundy, P. K., and Spiro, H. M. (1962). “Apprehension and elevated serum cortisol levels.” J. psychosom. Res., 6, 83–86.Google Scholar
13 Dorfman, R. J., and Ungar, F. (1965). Metabolism of Steroid Hormones. New York: Academic Press.Google Scholar
14 Elmadjian, F. (1955). “Adrenocortical function of combat infantrymen in Korea.” Ciba Foundation Coll. Endocrin., 8, 627.Google Scholar
15 Ferguson, H. C., Bartram, A. C. G., Fowlie, H. C., Cathro, D. M., Birchell, K., and Mitchell, F. L. (1964). “A preliminary investigation of steroid excretion in depressed patients before and after electroconvulsive therapy.” Acta endocrinol., 47, 58–68.Google Scholar
16 Fishman, J. R., Hamburg, D. A., Handlin, J. H., Mason, J. W., and Sacher, E. (1962). “Emotional and adrenal cortical responses to a new experience.” Arch. gen. Psychiat. (Chic.), 6, 271–278.Google Scholar
17 Frost, J. W., Dryer, R. L., and Kohlstaedt, K. G. (1951). “Stress studies on auto race drivers.” J. lab. clin. Med., 38, 523–525.Google Scholar
18 Fukushima, D. K., Bradlow, H. L., Hellman, L., Zumoff, B., and Gallagher, T. F. (1960). “Metabolic transformation of hydrocortisone C14 in normal men.” J. biol. Chem., 235, 2246–2252.CrossRefGoogle Scholar
19 Gallagher, T. F. (1959). In Biochemistry of Steroids (Mosettig, E., Ed.), 143. London: Pergamon.Google Scholar
20 Hamburg, D. A. (1966). Effects of Progesterone on Behavior, in Endocrines, and the Central Nervous System (Levine, R., Ed.). Baltimore: Williams & Wilkins Co.Google Scholar
21 Hamilton, M. (1960). “A rating scale for depression.” J. Neurol. Neurosurg. Psychiat., 23, 56–62.Google Scholar
22 Hill, S. R. Jr., Goetz, F. C., Fox, H. M., Murawski, B. J., Krakauer, L. J., Reifenstein, R. W., Gray, S. J., Reddy, W. J., Hedbero, S. E., St. Mara, J. R., and Thorn, G. W. (1956). “Studies on adrenocortical and psychological response to stress in man.” Arch. int. Med., 97, 269–298.CrossRefGoogle Scholar
23 Holmes, T. H., Hawkins, N. G., Bowerman, C. E., Clark, E. R., and Joffe, J. R. (1957). “Psychosocial and psychophysiologic studies of tuberculosis.” Psychosom. Med., 19, 134–143.Google Scholar
24 Jakobson, T., Stenback, A., Strandstrom, L., and Rimon, R. (1966). “The excretion of urinary 11-deoxy- and 11-oxy-17-hydroxy-corticosteroids in depressive patients during basal conditions and during the administration of metho-pyropene.” J. psychosom. Res., 9, 363–374.CrossRefGoogle Scholar
25 Kane, F. J., Daly, R. J., Ewing, J. A., Keeler, M. H., and Flowers, C. E. Jr. (1966). “Oral contraceptives as psychopharmacologic agents.” Current Psychiatric Therapies, 6, 219–221.Google Scholar
26 Mendels, J. (1967). “The prediction of response to electroconvulsive therapy.” Amer. J. Psychiat., 124, 153–159.CrossRefGoogle Scholar
27 Mills, I. H. (1964). Clinical Aspects of Adrenal Function. Philadelphia: F. A. Davis & Co.Google Scholar
28 Oken, D., Grinker, R. R., Heath, H. A., Sabshin, M., and Schwartz, N. (1960). “Stress responses in a group of psychiatric patients.” Arch. gen. Psychiat. (Chic.), 3, 451–466.Google Scholar
29 Persky, H., Grinker, R. R., Hamburg, D. A., Sabshin, M. A., Korchin, S. J., Basowitz, H., and Chevalier, J. A. (1956). “Adrenal cortical function in anxious human subjects: plasma levels and urinary excretion of hydrocortisone.” Arch. Neurol. Psychiat. (Chic.), 76, 549–558.Google Scholar
30 Prunty, F. T. G. (1964). Chemistry and Treatment of Adrenocortical Diseases. Springfield: Chas. C. Thomas.Google Scholar
31 Rubin, R. T., and Mandell, A. J. (1966). “Adrenal cortical activity in pathological emotional states: a review.” Amer. J. Psychiat., 123, 387–400.CrossRefGoogle Scholar
32 Scott, J. W., and Brass, P. (1966). “Massive norethynodrel therapy in the treatment of endometriosis.” Amer. J. Obstet. Gynecol., 95, 1166–1167.Google Scholar
33 Sobel, C., Golub, O. J., Henry, R. J., Jacobs, S. L., and Basu, G. K. (1958). “Study of the Norymberski methods for determination of 17-ketogenic steroids (17-hydroxycorticosteroids) in urine.” J. clin. Endocrinol. Metab., 18, 208–221.CrossRefGoogle Scholar
34 Sobel, C., Golub, O. J., Henry, R. J., Jacobs, S. L., and Basu, G. K. (1967). Personal communication.Google Scholar
35 von Euler, U. S., Gemzell, C. A., Levi, L., and Strom, G. (1959). “Cortical and medullary adrenal activity in emotional stress.” Acta endocr., 30, 567–573.Google Scholar
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