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TRH Response Pattern in Adolescent Schizophrenic Males

Published online by Cambridge University Press:  29 January 2018

Lawrence DeMilio
Lawrence DeMilio*
Affiliation:
Fair Oaks Hospital, 19 Prospect Street, Summit, New Jersey 07901, USA
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Summary

A marked elevation in human growth hormone (GH) following intravenous infusion of thyrotropin releasing hormone (TRH) was seen in three of seven adolescent male schizophrenic patients receiving neuroleptic drugs, and in one of five controls matched for age, sex, and developmental stage, receiving the same drugs. A positive family history for schizophrenia was noted in all three schizophrenic ‘responders' but in only one of the remaining patients. The response patterns of thyroid stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4 following TRH infusion were not significantly different in the two groups. No significant correlations were found between T3, T4, TSH, or GH response patterns and age of patient, duration of illness, medication dose or duration, weight change, or hours of sleep preceding testing.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 145 , Issue 6 , December 1984 , pp. 649 - 651
Copyright
Copyright © 1984 The Royal College of Psychiatrists 

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