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Treatment of Depression

A Comparative Trial of Imipramine and Desipramine

Published online by Cambridge University Press:  29 January 2018

John T. Rose  and
T. T. Westhead
John T. Rose
Affiliation:
Department of Psychiatry, Regional Neurological Unit and Regional Neurosurgical Unit, Walton Hospital, Liverpool 9
T. T. Westhead
Affiliation:
Prudhoe Hall Hospital, Prudhoe on Tyne, Northumberland
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Extract

Desipramine (Pertofran) is the monomethyl analogue of imipramine (Tofranil) and is marketed as a potent anti-depressant agent. The literature on this drug has already been adequately reviewed by Rose et al. (1964) and Waldron et al. (1965). It is therefore sufficient to note that earlier reports claiming a more rapid action than imipramine have not been supported by more recent investigations. This paper reports a double-blind controlled comparison of imipramine and desipramine, designed to investigate the relative effectiveness, speed of action and side-effects of these two drugs.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 113 , Issue 499 , June 1967 , pp. 659 - 665
Copyright
Copyright © Royal College of Psychiatrists, 1967 

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References

Ball, J. R. B., and Kiloh, L. G. (1959). “A controlled trial of imipramine in treatment of depressive states.” Brit. med. J., ii, 1052.Google Scholar
Brodie, B. B., Bickel, M. H., and Sulser, F. (1961). “Desmethylimipramine, a new type of antidepressant drug.” Med. Exp., 5, 454.Google Scholar
Fleminger, J. J., and Groden, B. M. (1962). “Clinical features of depression and the response to imipramine.” J. ment. Sci., 108, 101.Google Scholar
Hamilton, M. (1960). “A rating scale for depression.” J. Neurol. Neurosurg. Psychiat., 23, 56.Google Scholar
Kiloh, L. G., Ball, J. R. B., and Garside, R. F. (1962). “Prognostic factors in treatment of depressive states with imipramine.” Brit. med. J., i, 1225.Google Scholar
Mayer-Gross, W. (1954). “The diagnosis of depression.” Brit. med. J., ii, 948.Google Scholar
Rose, J. T., and Westhead, T. T. (1964). “Comparison of desipramine and imipramine in depression.” Amer. J. Psychiat., 121, 496.Google Scholar
Sulser, F., Watts, J., and Brodie, B. B. (1962). “On the mechanism of antidepressant action of imipramine-like drugs.” Ann. N.Y. Acad. Sci., 96, 279.Google Scholar
Waldron, J., and Bates, T. J. N. (1965). “The management of depression in hospital. A comparative trial of desipramine and imipramine.” Brit. J. Psychiat., 111, 511.Google Scholar
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