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Treatment of Alzheimer's Disease

Molecular Pathology Versus Neurotransmitter-Based Therapy

Published online by Cambridge University Press:  02 January 2018

David M. Bowen
David M. Bowen*
Affiliation:
Miriam Marks Department of Neurochemistry, Institute of Neurology (Queen Square), 1 Wakefield Street, London WC1N 1PJ
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Extract

Cortical inhibitory neurotransmitters, neuropeptides, dopamine and noradrenaline are probably either not selectively or not critically affected in AD. It is, however, likely that a key change is shrinkage or loss of corticocortical pyramidal neurones, which probably use glutamate as their transmitter. This depletion appears to be circumscribed and clinically relevant.

Type
Comment
Information
The British Journal of Psychiatry , Volume 157 , Issue 3 , September 1990 , pp. 327 - 330
Copyright
Copyright © Royal College of Psychiatrists, 1990 

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