Hostname: page-component-745bb68f8f-v2bm5 Total loading time: 0 Render date: 2025-01-12T00:45:57.796Z Has data issue: false hasContentIssue false
  • English
  • Français

Serum Immunoglobulin Concentrations in Patients Admitted to an Acute Psychiatric In-patient Service

Published online by Cambridge University Press:  29 January 2018

Lynn E. DeLisi ,
Catherine King  and
Steven Targum
Lynn E. DeLisi*
Affiliation:
Section of Psychogenetics, 9000 Rockville Pike, Building 10, Room 3N220, Bethesda, MD 20205, USA
Catherine King
Affiliation:
Section of Clinical Brain Imaging, Laboratory of Psychology and Psychopathology, The National Institute of Mental Health
Steven Targum
Affiliation:
The Psychiatric Institute, Sarasota Palms Hospital, Sarasota, Florida, USA
*
∗Correspondence
Get access Rights & Permissions [Opens in a new window]

Summary

Serum immunoglobulins were quantified in 85 consecutively admitted patients from an acute-care psychiatric in-patient unit. The patients were diagnosed as: major depressive disorder, 53; chronic schizophrenia, 12; schizophreniform psychosis, 4; substance abuse disorder, 12; and miscellaneous other diagnoses, 4. A small sub-group of these patients, which included six with major depression, one with chronic schizophrenia, and one with a personality disorder, were found to have low IgM concentrations. Immunoglobulin levels were not associated with use of medication or length of illness prior to this hospital admission. This study provides further evidence for suppression of humoral immunity in some psychiatric patients (approximately 10%).

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 145 , Issue 6 , December 1984 , pp. 661 - 665
Copyright
Copyright © 1984 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Albrecht, P., Torrey, E. F., Boone, E., Hicks, J. & Daniel, N. (1980) Raised cytomegalovirus-antibody levels in cerebrospinal fluid of schizophrenic patients. Lancet 2, 769–72.Google Scholar
Amkraut, A., Solomon, G. F., Allansmith, M., McClellan, G. & Rappaport, M. (1973) Immunoglobulins and improvement in acute schizophrenic reactions. Archives of General Psychiatry, 28, 673–7.Google Scholar
Bartrop, R. W., Lazarus, L., Luckhurst, E. & Kiloh, L. G. (1977) Depressed lymphocyte function after bereavment. Lancet, i, 834–6.Google Scholar
Bock, E., Weeke, B. & Rafaelson, O. J. (1970) Immunoglobulins in schizophrenic patients. Lancet, 2, 523.CrossRefGoogle ScholarPubMed
DeLisi, L. E. & Wyatt, R. J. (1984) Neurochemical aspects of schizophrenia. In Handbood of Neurochemistry, Vol. 10, (ed. Lajtha, A.). (in press).Google Scholar
DeLisi, L. E. Weinberger, D. R., Neckers, L. M., Potkin, S., Shiling, D. J. & Wyatt, R. J. (1981) Quantitive determination of immunoglobulins in CSF and plasma of chronic schizophrenic patients. British Journal of Psychiatry, 139, 513–9.Google Scholar
Domino, E. F., Krause, R. R., Thiessen, M. M. & Batsakis, J. G. (1975) Blood protein fraction comparisons of normal and schizophrenic patients. Archives of General Psychiatry, 32, 717–21.Google Scholar
Endicott, J., Spitzer, R. L., Fleiss, J. L. & Cohen, J. (1976) The Global Assessment Scale: a procedure for measuring overall severity of psychiatric disturbance. Archives of General Psychiatry, 33, 766–72.CrossRefGoogle Scholar
Evans, N. J. R., Baldwin, J. A. & Gath, D. (1974) The incidence of cancer among inpatients with affective disorders. British Journal of Psychiatry, 124, 518–25.Google Scholar
Hall, R. C. W., Gardner, E. R., Stickney, S. K., LeCann, A. F. & Popkin, M. K. (1980) Physical illness manifesting as psychiatric disease. Archives of General Psychiatry, 37, 989–95.Google Scholar
Hendrie, H. C., Paraskivas, F. & Varsamis, J. (1972) Gamma globulin levels in psychiatric patients. Canadian Psychiatric Association Journal, 17, 93–7.Google Scholar
Johnstone, E. C. & Whaley, K. (1975) Antinuclear antibodies in psychiatric illness: their relationship to diagnosis and drug treatment. British Medical Journal, 2, 724–5.Google Scholar
Kronfol, Z., Silva, J., Greden, J., Dembinski, S., Gardner, R. & Carroll, B. (1983) Impaired lymphocyte function in depressive illness. Life Science, 18, 241–7.Google Scholar
McGuffin, P. (1980) What have transplant antigens got to do with psychoses? British Journal of Psychiatry, 136, 510–2.Google Scholar
Pulkkinen, E. (1977) Immunoglobulins, psychopathology and prognosis in schizophrenia. Acta Psychiatrica Scandinavica, 56, 173–82.Google Scholar
Schleifer, S. J., Keller, S. E., Camerino, M., Thornton, J. C. & Stein, M. (1983) Suppression of Lymphocyte stimulation following bereavment. Journal of the American Medical Association, 250, 374–7.Google Scholar
Solomon, G. F., Allansmith, M., McClellan, B. & Amkraut, A. (1969) Immunoglobulins in psychiatric patients. Archives of General Psychiatry, 20, 272–7.Google Scholar
Strahilevitz, M. & Davis, S. D. (1970) Increased IgA in schizophrenic patients. Lancet, 2, 370.Google Scholar
Strahilevitz, M. Fleischman, J. B., Fischer, G. W., Harris, R. & Narasimhachari, N. (1976) Immunoglobulin levels in psychiatric patients. American Journal of Psychiatry, 133, 772–7.Google Scholar
Sugarman, A. A., Southern, D. L., Curran, J. F. (1982) A study of antibody levels in alcoholic depressive and schizophrenic patients. Annals of Allergy, 48, 166–71.Google Scholar
Torrey, E. F., Peterson, M. R., Brannon, W. L., Carpenter, W. T., Post, R. M. & Van Kammen, D. P. (1980) Immunoglobulins and viral antibodies in psychiatric patients. British Journal of Psychiatry, 132, 342–8.Google Scholar
Torrey, E. F. Yolken, R. H. & Winfrey, C. J. (1982) Cytomegalovirus antibody in cerebrospinal fluid of schizophrenic patients detected by enzyme immunoassay. Science, 216, 892–4.Google Scholar
Zarrabi, M. H., Zucker, S., Miller, F., Derman, R. M., Romano, G. S., Hartnett, J. A. & Varma, A. O. (1979) Immunologie and coagulation disorders in chlorpromazine treated patients. Annals of Internal Medicine, 91, 194–9.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.