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A Search for ‘Schizophrenia Spectrum Disorders’: An Application of a Multiple Threshold Model to Blind Family Study Data

Published online by Cambridge University Press:  29 January 2018

Ming T. Tsuang ,
Kathleen D. Bucher  and
Jerome A. Fleming
Ming T. Tsuang
Affiliation:
Brown University; Psychiatric Epidemiology Research Unit, Butler Hospital, 345 Blackstone Boulevard, Providence, Rhode Island 02906, USA
Kathleen D. Bucher
Affiliation:
Department of Preventive Medicine and Environmental Health, University of Iowa College of Medicine; Department of Human Genetics, University of Michigan
Jerome A. Fleming
Affiliation:
Psychiatric Epidemiology Research Unit, Butler Hospital, Providence, Rhode Island
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Summary

Family data from schizophrenic and control probands were analyzed using a descriptive analysis and multiple threshold models to determine whether a given group of diagnoses made in accordance with ICD–9 was aetiologically related to schizophrenia. The proportion of relatives receiving any psychiatric diagnosis, other than schizophrenia and affective disorder, was essentially the same between the two study groups. Furthermore, the data did not fit the multiple threshold model tested. Thus, the hypothesis that schizophrenia and a spectrum of disorders defined according to ICD–9 have a common familial aetiology was not accepted.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 143 , Issue 6 , December 1983 , pp. 572 - 577
Copyright
Copyright © 1983 The Royal College of Psychiatrists 

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