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Research on Symptoms Versus Research on Syndromes

Arguments in Favour of Allocating More Research Time to the Study of Symptoms

Published online by Cambridge University Press:  02 January 2018

Charles G. Costello
Charles G. Costello*
Affiliation:
Department of Psychology, University of Calgary, 2500 University Drive, NW, Calgary, Alberta, Canada
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Abstract

Research on symptoms may often be more fruitful than research on syndromes because: (a) the validities of psychiatric diagnoses remain questionable; (b) interview assessments of a large number of symptoms are inadequate; (c) the diagnostic approach results in problems of misclassification and confounding; (d) the dimensional/categorical issue may be more readily resolved with research using a symptom approach; (e) useful animal models of symptoms are more likely to be developed than useful animal models of syndromes; and (f) symptoms may be better phenotypes than syndromes in genetic research.

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Information
The British Journal of Psychiatry , Volume 160 , Issue 3 , March 1992 , pp. 304 - 308
Copyright
Copyright © Royal College of Psychiatrists, 1992 

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References

American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (DSM–III–R) (3rd edn, revised). Washington DC: APA.Google Scholar
Baron, M. (1987) Genetic models and the transmission of schizophrenia. In Searches for the Causes of Schizophrenia (eds Hafner, H., Gattaz, W. F., Janzarik, W.). Berlin: Springer-Verlag.Google Scholar
Beninnger, R. J. (1988) The slow therapeutic action of antipsychotic drugs. In Animal Models of Psychiatric Disorders (eds Simon, P., Soubrié, P. & Wildlocher, D.). Basel: Karger.Google Scholar
Berenbaum, H., Oltmanns, T. F. & Gottesman, I. (1985) Formal thought disorder in schizophrenics and their twins. Journal of Abnormal Psychology, 94, 3–16.CrossRefGoogle ScholarPubMed
Blaney, P. H. (1986) Affect and memory: a review. Psychological Bulletin, 99, 229–246.CrossRefGoogle ScholarPubMed
Brockington, I. F., Helzer, J. E., Hillier, V. F., et al (1982) Definitions of depression: concordance and prediction of outcome. American Journal of Psychiatry, 139, 1022–1027.Google ScholarPubMed
Chapman, L. J., Chapman, J. P. & Raulin, M. L. (1976) Scales for physical and social anhedonia. Journal of Abnormal Psychology, 85, 374–382.Google Scholar
Chapman, L. J., Chapman, J. P., Raulin, M. L. (1978) Body-image aberration in schizophrenia. Journal of Abnormal Psychology, 87, 399–407.Google Scholar
Chapman, L. J., Chapman, J. P., Numbers, J. A., et al (1984) Impulsive nonconformity as a trait contributing to the prediction of psychotic-like and schizotypal symptoms. Journal of Nervous and Mental Disease, 172, 681–691.Google Scholar
Costello, C. G. (1970a) Classification and psychopathology. In Symptoms of Psychopathology (ed. Costello, C. G.), pp. 1–26. New York: John Wiley & Sons.Google Scholar
Costello, C. G. (1970b) Dissimilarities between conditioned avoidance responses and phobias. Psychological Review, 77, 250–254.Google Scholar
Dean, C., Surtees, P. G. & Sashidharan, S. P. (1983) Comparison of research diagnostic systems in an Edinburgh community sample. British Journal of Psychiatry, 142, 247–256.Google Scholar
DeVeaugh-Geiss, J. (1988) On dropsy, dementia and drug discovery. Animal Models of Psychiatric Disorders, 1, 189–191.Google Scholar
Eckblad, M. & Chapman, L. J. (1983) Magical ideation as an indicator of schizotypy. Journal of Abnormal Psychology, 51, 215–225.Google Scholar
Eysenck, H. J. & Eysenck, S. B. G. (1975) Manual for the Eysenck Personality Questionnaire (Junior and Adult). San Diego, California: Educational and Industrial Testing Service.Google Scholar
Eysenck, H. J. & Eysenck, S. B. G. (1976) Psychoticism as a Dimension of Personality. London: Hodder & Stoughton.Google Scholar
Hamilton, M. (1960) A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 56–62.CrossRefGoogle ScholarPubMed
Harvey, P. D. & Neale, J. M. (1983) The specificity of thought disorder to schizophrenia: research methods in their historical perspective. In Progress in Experimental Personality Research, vol. 12 (ed. Maher, B.). New York: Academic Press.Google Scholar
Healy, D. (1987) The comparative psychopathology of affective disorders in animals and humans. Journal of Psychopharmacology, 1, 193–210.Google Scholar
Heilbrun, A. B. (1980) Impaired recognitions of self-expressed thought in patients with auditory hallucinations. Journal of Abnormal Psychology, 89, 728–736.CrossRefGoogle ScholarPubMed
Heilbrun, A. B. & Blum, N. A. (1984) Cognitive vulnerability to auditory hallucination: impaired assignment of meaning. British Journal of Psychiatry, 144, 508–512.Google Scholar
Hinde, R. A. (1976) The use of differences and similarities in comparative psychopathology. In Animal Models in Human Psychobiology, pp. 187–202. New York: Plenum.Google Scholar
Kahn, R. L., Zarit, S. H., Hilbert, N. M., et al (1975) Memory complaint and impairment in the aged: the effect of depression and altered brain function. Archives of General Psychiatry, 32, 1569–1573.Google Scholar
Kidd, K. K. & Matthyse, S. (1978) Research designs for the study of gene-environmental interactions in psychiatric disorders: report of a Foundations Fund for Research in Psychiatry panel. Archives of General Psychiatry, 35, 925–931.Google Scholar
Manschreck, T. C. (1989) Motor abnormalities and the psychopathology of schizophrenia. In Normalities and Abnormalities in Human Movement. (ed. Kirkcaldy, B.), pp. 100–127. Basel: Karger.Google Scholar
Manschreck, T. C., Maher, B. A. & Aden, D. N. (1981a) Formal thought disorder, the type-token ratio, and disturbed voluntary motor movement in schizophrenia. British Journal of Psychiatry, 139, 7–15.Google Scholar
Manschreck, T. C., Maher, B. A., Rucklos, M. E., et al (1981b) Deficient motor synchrony in schizophrenia. Journal of Abnormal Psychology, 90, 321–328.CrossRefGoogle ScholarPubMed
Manschreck, T. C., Maher, B. A., Rucklos, M. E., et al (1982) Disturbed voluntary motor activity in schizophrenic disorders. Psychological Medicine, 12, 73–84.Google Scholar
Manschreck, T. C., Maher, B. A., Waller, N. G., et al (1985) Deficient motor synchrony in schizophrenic disorders: clinical correlates. Biological Psychiatry, 20, 990–1002.Google Scholar
Mazure, C., Nelson, J. C. & Price, L. H. (1986) Reliability and validity of the symptoms of major depressive illness. Archives of General Psychiatry, 43, 451–456.Google Scholar
McNally, R. J. (1987) Preparedness and phobias: a review. Psychological Bulletin, 101, 283–303.Google Scholar
Overmier, J. B. & Hellhammer, D. H. (1988) The learned helplessness model of human depression. Animal Models of Psychiatric Disorder, 2, 177–202.Google Scholar
Penrose, L. S. (1971) Psychiatric genetics. Psychological Medicine, 1, 265–266.Google Scholar
Persons, J. B. (1986) The advantages of studying psychological phenomena rather than psychiatric diagnoses. American Psychologist, 41, 1252–1260.Google Scholar
Post, R. M. & Weiss, S. R. B. (1988) Stimulant-induced behavioral sensitization: a model for neuroleptic nonresponsiveness. In Animal Models of Psychiatric Disorders (eds Simon, P., Soubrié, P. & Wildlocher, D.). Basel: Karger.Google Scholar
Raulin, M. L. (1984) Development of a scale to measure intense ambivalence. Journal of Consulting and Clinical Psychology, 52, 63–72.Google Scholar
Robins, L. N. (1989) Diagnostic grammar and assessment: translating criteria into questions. Psychological Medicine, 19, 57–68.Google Scholar
Robins, L. N., Helzer, J. E., Croughan, J., et al (1981) NIMH Diagnostic Interview Schedule Version III. Washington, DC: National Institute of Mental Health.Google Scholar
Sashidharan, S. P. (1985) Definitions of psychiatric syndromes: comparison in hospital patients and general population. British Journal of Psychiatry, 147, 547–551.Google Scholar
Seligman, M. E. P. (1975) Helplessness: on Depression, Development and Death. San Francisco: W. H. Freeman.Google Scholar
Strauss, J. S. (1969) Hallucinations and delusions as points on continua function: rating scale evidence. Archives of General Psychiatry, 21, 581–586.Google Scholar
Szabadi, E., Bradshaw, C. M. & Besson, I. A. O. (1976) Elongation of pause-time in speech: a simple objective measure of motor retardation in depression. British Journal of Psychiatry, 129, 592–597.Google Scholar
Van den Brink, W., Koeter, M. W. J., Ormel, J., et al (1989) Psychiatric diagnosis in an outpatient population. Archives of General Psychiatry, 46, 369–372.Google Scholar
Watts, F. N. & Sharrock, R. (1985) Description and measurement of concentration problems in depressed patients. Psychological Medicine, 15, 317–326.Google Scholar
Watts, F. N., MacLeod, A. K. & Morris, L. (1988) A remedial strategy for memory and concentration problems in depressed patients. Cognitive Therapy and Research, 12, 185–193.Google Scholar
Willner, P. (1985) Depression: a Psychobiological Synthesis. New York: John Wiley & Sons.Google Scholar
Wing, J. K. (1988) Abandoning what? British Journal of Clinical Psychology, 27, 325–328.Google Scholar
Wing, J. K., Cooper, J. & Sartorius, N. (1974) The Measurement and Classification of Psychiatric Symptoms. Cambridge: Cambridge University Press.Google Scholar
Zimmerman, M. (1988) Why are we rushing to publish DSM–IV? Archives of General Psychiatry, 45, 1135–1138.Google Scholar
Zisook, S., Click, N. & Jaffe, K. (1980) Research criteria for the diagnosis of depression. Psychiatry Research, 2, 13–23.Google Scholar
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