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Randomised double-blind comparison of the incidence of tardive dyskinesia in patients with schizophrenia during long-term treatment with olanzapine or haloperidol

Published online by Cambridge University Press:  02 January 2018

Charles M. Beasley Jr ,
Mary Anne Dellva ,
Roy N. Tamura ,
Hal Morgenstern ,
William M. Glazer ,
Kevin Ferguson  and
Gary D. Tollefson
Charles M. Beasley Jr*
Affiliation:
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN
Mary Anne Dellva
Affiliation:
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN
Roy N. Tamura
Affiliation:
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN
Hal Morgenstern
Affiliation:
School of Public Health, University of California at Los Angeles
William M. Glazer
Affiliation:
Harvard Medical School, Boston, MA
Kevin Ferguson
Affiliation:
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
Gary D. Tollefson
Affiliation:
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
*
Charles M. Beasley, Jr, MD, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Drop Code 0538, Indianapolis, IN 46285, USA. Tel: (317) 276-4994; Fax: (317)277-7839
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Abstract

Background

Tardive dyskinesia is important in the side-effect profile of antipsychotic medication.

Aims

The development of tardive dyskinesia was evaluated in patients treated with double-blind, randomly assigned olanzapine or haloperidol for up to 2.6 years.

Methods

Tardive dyskinesia was assessed by the Abnormal Involuntary Movement Scale (AIMS) and Research Diagnostic Criteria for Tardive Dyskinesia (RD-TD); it was defined as meeting RD-TD criteria at two consecutive assessments. The risk of tardive dyskinesia, the relative risk, incidence rate, and incidence rate ratio were estimated.

Results

The relative risk of tardive dyskinesia for the overall follow-up period for haloperidol (n=522) v. olanzapine (n=1192) was 2.66 (95% CI=1.50–4.70). Based on data following the initial six weeks of observation (during which patients underwent medication change and AIMS assessments as frequently as every three days), the one-year risk was 0.52% with olanzapine (n=513) and 7.45% with haloperidol (n=114). The relative risk throughout this follow-up period was 11.37 (95% Cl=2.21–58.60).

Conclusion

Our results indicated a significantly lower risk of tardive dyskinesia with olanzapine than with haloperidol.

Type
Papers
Information
The British Journal of Psychiatry , Volume 174 , Issue 1 , January 1999 , pp. 23 - 30
Copyright
Copyright © 1999 The Royal College of Psychiatrists 

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Footnotes

Declaration of interest

Sponsored by Eli Lilly and Company.

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