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Psychotic Illness in Multiple Sclerosis

A Clinical and Magnetic Resonance Imaging Study

Published online by Cambridge University Press:  02 January 2018

Anthony Feinstein ,
George Du Boulay  and
Maria A. Ron
Anthony Feinstein*
Affiliation:
Institute of Neurology, Queen Square, London WC1N 3BG
George Du Boulay
Affiliation:
Institute of Neurology, Queen Square, London WC1N 3BG
Maria A. Ron
Affiliation:
The Institute of Neurology, Queen Square, London WC1N 3BG
*
∗Correspondence
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Abstract

Ten patients with multiple sclerosis (MS) and psychosis were assessed using the Present State Examination, and matched retrospectively with respect to age, disability, duration of symptoms, and disease type with 10 MS patients without psychosis. Both groups underwent MRI of the brain. There was a trend for the psychotic group to have a higher total lesion score, particularly around the periventricular areas. This reached statistical significance in the areas around the temporal horn. In all cases, neurological symptoms preceded the onset of psychosis. The psychotic group also had a later age of onset of psychosis than psychotic patients without brain disease. These results point to an aetiological association between the pathological process of MS and psychosis.

Type
Papers
Information
The British Journal of Psychiatry , Volume 161 , Issue 5 , November 1992 , pp. 680 - 685
Copyright
Copyright © 1992 The Royal College of Psychiatrists 

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