Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-05T09:33:14.824Z Has data issue: false hasContentIssue false
  • English
  • Français

Psychophysiologic Changes accompanying Oral Contraceptive Use

Published online by Cambridge University Press:  29 January 2018

David B. Marcotte ,
Francis J. Kane ,
Paul Obrist  and
Morris A. Lipton
David B. Marcotte
Affiliation:
University of North Carolina School of Medicine, Chapel Hill, N.C.
Francis J. Kane
Affiliation:
University of North Carolina School of Medicine, Chapel Hill, N.C.
Paul Obrist
Affiliation:
University of North Carolina School of Medicine, Chapel Hill, N.C.
Morris A. Lipton
Affiliation:
University of North Carolina School of Medicine, Chapel Hill, N.C.
Get access Rights & Permissions [Opens in a new window]

Extract

There have been many studies (3,15,4) on the effects of oral contraceptive hormonal agents, though relatively few have concerned themselves with the possible adverse emotional reactions accompanying their use. To date, seven women (8, 6, 5, 13) have had psychotic episodes in temporal association with drug use, one patient having reported two such episodes. Four of these seven women had a history of severe postpartum disturbance in the past, and two others had previous psychiatric illness. There have been reports of varying incidence of depression, anxiety, increased or decreased sexual desire and relief of premenstrual tension. We wish to present data from a pilot double blind study of one combination oral contraceptive.

Type
Abstract
Information
The British Journal of Psychiatry , Volume 116 , Issue 531 , February 1970 , pp. 165 - 167
Copyright
Copyright © Royal College of Psychiatrists, 1970 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Crout, R. J. (1961). ‘Gatecholaminces in urine’, in Standard Methods in Clinical Chemistry. Ed. Seligson, D. Academic Press, New York. 3, 62.Google Scholar
2. Daly, R. J., Kane, F. J., and Ewing, J. A. (1967). ‘Psychosis associated with use of a sequential oral contraceptive.’ Lancet, ii, 444–5.Google Scholar
3. Food and Drug Administration Report on Oral Contraceptives by the Advisory Committee on Obstetrics and Gynecology, FDA, August 1 1966. Available from the U.S. Government Printing Office, Washington, D.G. 20402.Google Scholar
4. Gligk, I. D. (1967). ‘Mood and behavioural changes associated with the use of oral contraceptive agents.’ Psychopharmacologia., 10, 363.CrossRefGoogle Scholar
5. Idestrom, G. M. (1966). ‘Reaction to norethisterone withdrawal.’ Lancet, i, 718.CrossRefGoogle Scholar
6. Kane, F. J., Treadway, G. R., and Ewing, J. A. ‘Emotional change associated with oral contraceptives in psychiatric and non-psychiatric patients.’ (Unpublished data.) Google Scholar
7. Kear-Colwell, J. J. (1965). ‘Neuroticism in the early puerperium.’ Brit. J. Psychiat., III, 1189–92.Google Scholar
8. Keeler, M. H., Daly, R., and Kane, F. J. (1964). ‘An acute schizophrenic episode following abrupt withdrawal of Enovid in a patient with previous postpartum psychiatric disorder.’ Amer.J. Psychiat., 120, 11, 1123–24.Google Scholar
9. Keeler, M. H., Prange, A. J., and Reifler, G. B. (1966). ‘Effects of imipramine and thioridazine on set and attention.’ Dis. nerv. Sys., 27, 798-802.Google Scholar
10. McKinney, W. T. Jr., Prange, A. J., Cochrane, G. M., Keeler, M. H., Reifler, G. B. (1967). ‘Imipramine and thioridazine-lack of peri-pheral effects.’ Dis. nerv. Sys., 28, 402–5.Google Scholar
11. Masters, R., and Johnson, V. Human Sexual Response, p. III.Google Scholar
12. Miller, J. W., and Green, R. D. (1966). ‘Catechol-amine concentrations: changes in plasma of rats during estrous cycle and pregnancy.’ Science. 151, 852.Google Scholar
13. Murawski, B. J., Sapir, E. P., et al. (1968). ‘An investigation of mood states in women taking oral contraceptives.’ Fertility and Sterility. 19, 50–63.Google Scholar
14. Nowlis, V. (1965). ‘Research with the mood adjective check list’, in Affect, Cognition and Personality, Tomkins, S. S., and Izard, E. G. (Editors), New York; Springer, pp. 353–89.Google Scholar
15. Pincus, G. (1966). ‘Control of conception by hormonal steroids.’ Science, 153, 493.CrossRefGoogle ScholarPubMed
16. Pisano, J. J., Crout, R. J., and Abraham, D. (1962). ‘Determination of 3-methocy-4-hydroxymandelic acid in urine.’ Clin. Chem. Acta, 7, 285–91.Google Scholar
17. Porter, C. C., and Silber, R. H. (1950). ‘A quantitative color reaction for cortisone and related 17, 21-dihydroxy-20 ketosteroids.’ J. biol. Chem., 85, 201–7.Google Scholar
18. Spratto, G., and Miller, J. W. (1968). ‘An investigation of the mechanism by which estradiol 17-B elevates the epinephrine content of the rat uterus’, J. Pharm. exp. Ther., 161, 7-13.Google Scholar
19. Taniguchi, K., Kakimoto, Y., and Armstrong, M. D. (1964). ‘Quantitative determination of metanephrine and normetanephrine in urine.’ J. Lab. clin. Med., 64, 469–84.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.