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A Psychiatric Investigation of Triple-X Chromosome Females

Published online by Cambridge University Press:  29 January 2018

Cecil B. Kidd ,
R. S. Knox  and
D. J. Mantle
Cecil B. Kidd
Affiliation:
Medical Research Council Unit for Research on the Epidemiology of Psychiatric Illness, Department of Psychological Medicine, University of Edinburgh
R. S. Knox
Affiliation:
Medical Research Council Unit for Research on the Epidemiology of Psychiatric Illness, Department of Psychological Medicine, University of Edinburgh
D. J. Mantle
Affiliation:
Medical Research Council, Research Unit on Clinical Effects of Radiation, Western General Hospital, Edinburgh
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Extract

Among recent developments in human chromosome studies a triple-X state has been recognized in females in whom the chromosome number is 47, composed of 44 autosomes and 3 X chromosomes (Jacobs et al., 1959). Early surveys of nuclear sex have shown that the triple-X state is a not uncommon chromosomal anomaly. A survey of Edinburgh babies gave a frequency at birth of these abnormal females of 1.78/1,000 births (Court Brown, 1962) and by combining data of surveys from Edinburgh (Maclean et al., 1962), Glasgow (Fraser et al., 1960) and Baltimore (Johnston et al., 1961) the estimated frequency of the triple-X state in mental subnormality institutions is 4.51/1,000 in-patients.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 109 , Issue 458 , January 1963 , pp. 90 - 94
Copyright
Copyright © Royal College of Psychiatrists, 1963 

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