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Prevalence of Familiality, Obstetric Complications, and Structural Brain Damage in Schizophrenic Patients

Published online by Cambridge University Press:  02 January 2018

V. L. Nimgaonkar ,
S. Wessely  and
R. M. Murray
V. L. Nimgaonkar*
Affiliation:
Institute of Psychiatry, London
S. Wessely
Affiliation:
Maudsley Hospital
R. M. Murray
Affiliation:
Institute of Psychiatry, London
*
∗Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF
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Abstract

Schizophrenic in-patients with and without a family history were identified prospectively. The two groups did not differ with respect to clinical variables, ventricular enlargement, prevalence of cortical sulcal widening, or a history of obstetric complications, even when a variety of definitions of familiality were used.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 153 , Issue 2 , August 1988 , pp. 191 - 197
Copyright
Copyright © Royal College of Psychiatrists, 1988 

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References

Baron, M., Gruen, R. & Asnis, L. (1982) Schizophrenia: a comparative study of patients with and without family history. British Journal of Psychiatry, 140, 516–517.CrossRefGoogle ScholarPubMed
Bartko, J. J. & Carpenter, W. T. (1976) On the methods and theory of reliability. Journal Nervous and Mental Disease, 163, 307–317.Google Scholar
Cazzullo, C. L., Sacchetti, E., Vita, A., Illeni, M., Bellodi, L., Maffei, C., Alciati, A., Bertrand, O. P., Calzeroni, A., Guissani, S., Conte, G., Permati, A. & Invernizzi, G. (1985) Cerebral ventricular size in schizophrenia spectrum disorder: Relationship to clinical, neurophysiological and immunogenetic variables. Proceedings of the Fourth World Congress for Biological Psychiatry.Google Scholar
Campbell, R., Hays, P., Russell, D. B. & Zacks, D. J. (1979) CT scan variants and genetic heterogeneity in schizophrenia. American Journal of Psychiatry, 136, 722–723.Google ScholarPubMed
Dalen, P. (1972) One, two or many? In Genetic Factors in Schizophrenia (ed. Kaplan, E. R.), pp. 978–989. Springfield, Illinois: Charles C. Thomas.Google Scholar
Davis, J. M. (1976) Comparative doses and costs of antipsychotic medication. Archives of General Psychiatry, 33, 858–861.CrossRefGoogle ScholarPubMed
DeLisi, L. E., Goldin, L. R., Hamovit, J. R., Maxwell, M. E., Kurtz, D. & Gershon, E. S. (1986) A family study of the association of increased ventricular size with schizophrenia. Archives of General Psychiatry, 43, 148–153.CrossRefGoogle ScholarPubMed
Eaves, L. J., Kendler, K. S. & Schulz, S. C. (1986) The familial sporadic classification: its power for the resolution of genetic and environmental aetiological factors. Journal of Psychiatric Research, 20, 115–130.CrossRefGoogle Scholar
Endicott, J., Andreasen, N. & Spitzer, R. L. (1975) Family History Research Diagnostic Criteria. New York: New York State Psychiatric Institute.Google Scholar
Farmer, A., Jackson, R., McGuffin, P. & Storey, P. (1987) Cerebral ventricular enlargement in chronic schizophrenia: consistencies and contradictions. British Journal of Psychiatry, 150, 324–330.Google Scholar
Fletcher, J. M., Levin, H. S. & Landry, S. H. (1984) Behavioural consequences of cerebral insult in infancy. In Early Brain Damage (eds Almli, C. R. & Finger, S.) vol. 1. New York: Academic Press.Google Scholar
Goldin, L. R., DeLisi, L. E. & Gershon, E. S. (1987) Unravelling the relationship between environmental risk factors in psychiatric disorders. British Journal of Psychiatry, 151, 302–305.Google Scholar
Gottesman, I. I. & Shields, J. (1982) Schizophrenia, the Epigenetic Puzzle. Cambridge: Cambridge University Press.Google Scholar
Gottesman, I. I., McGuffin, P. & Farmer, A. (1987) Clinical genetics as clues to the ‘real’ genetics of schizophrenia. Schizophrenia Bulletin, 12, 23–48.CrossRefGoogle Scholar
Jacobsen, B. & Kinney, D. K. (1980) Perinatal complications in adopted and non-adopted schizophrenics and their controls: Preliminary results. Acta Psychiatrica Scandinavica, 62, Suppl. 285, 337–346.CrossRefGoogle Scholar
Kety, S. (1980) The syndrome of schizophrenia. British Journal of Psychiatry, 136, 437–444.CrossRefGoogle ScholarPubMed
Lane, E. A. & Albee, G. W. (1966) Comparative birth weights of schizophrenics and their siblings. Journal of Psychology, 64, 227–231.CrossRefGoogle Scholar
Leichty, E. A., Gilmore, R. L. M., Bryson, C. Q. & Bull, M. J. (1983) Outcome of high-risk neonates with ventriculomegaly. Developmental Medicine and Child Neurology, 25, 162–168.Google Scholar
Lewis, S. W. & Murray, R. M. (1987) Obstetric complications, neurodevelopmental deviance and risk of schizophrenia. Journal of Psychiatric Research, 21, 413–422.Google Scholar
Lewis, S. W., Reveley, A. M., Reveley, M. A., Chitkara, B. & Murray, R. M. (1987) The familial–sporadic distinction strategy in schizophrenia research. British Journal of Psychiatry, 151, 306–313.Google Scholar
Lishman, W. A. (1981) Cerebral disorder in alcoholism. Syndromes of impairment. Brain, 104, 1–20.Google Scholar
McCarton-Daum, C., Danziger, A., Ruff, H. & Vaughan, H. G. (1983) Periventricular low density as a predictor of neurobehavioural outcome in very low birthweight infants. Developmental Medicine and Child Neurology, 25, 559–565.Google Scholar
McNeil, T. F. (1986) Perinatal factors in the development of schizophrenia. Paper presented at the Workshop on Biological Perspectives in Schizophrenia, Dahlem, Berlin.Google Scholar
McNeil, T. F. & Kaij, L. (1978) Obstetric factors in the development of schizophrenia: Complications in the births of preschizophrenics and reproduction of schizophrenic parents. In High Risk and Premorbid Development (eds Wynne, C., Cromwell, R. L. & Mathysse, S.), pp. 407–429. New York: Wiley.Google Scholar
Murray, R. M., Lewis, S. W. & Reveley, A. M. (1985) Towards an aetiological classification of schizophrenia. The Lancet, i, 1023–1026.Google Scholar
Nasrallah, H. A., McCalley-Whitters, M. & Jacoby, C. G. (1982) Cortical atrophy in schizophrenia and mania: a comparative CT Study. Journal of Clinical Psychiatry, 43, 439–441.Google Scholar
Nasrallah, H. A., Kuperman, S., Hamra, B. J. & McCalley-Whitters, M. (1983) Differences between schizophrenic patients with and without large ventricles. Journal of Clinical Psychiatry, 44, 407–409.Google Scholar
Owen, M. J., Lewis, S. W. & Murray, R. M. (1988) Obstetric complications and cerebral abnormalities in schizophrenia. Psychological Medicine, 18, 331–340.Google Scholar
Owens, D. G. L., Johnstone, E. C., Crow, T. J., Frith, C. D., Jagoe, J. R. & Kreel, L. (1985) Lateral ventricular size in schizophrenia: relationship to the disease process and its clinical manifestations. Psychological Medicine, 15, 27–41.Google Scholar
Oxenstierna, G., Bergstrand, G., Bjerkenstedt, L., Sedvall, G. & Wik, G. (1984) Evidence of disturbed CSF circulation and brain atrophy in cases of schizophrenic psychoses. British Journal of Psychiatry, 144, 654–661.Google Scholar
Parnas, J., Schulsinger, F., Teasdale, T. W., Schulsinger, H., Feldman, P. M. & Mednick, S. A. (1982) Perinatal complications and clinical outcome within schizophrenia spectrum. British Journal of Psychiatry, 140, 416–420.Google Scholar
Pasamanick, B., Rogers, M. E. & Lilienfeld, A. (1956) Pregnancy experience and the development of childhood behavioural disorder. American Journal of Psychiatry, 112, 613–618.CrossRefGoogle Scholar
Pearlson, G. D., Garbacz, D. J., Moberg, P. J., Ahn, H. D. & DePaulo, J. R. (1985) Symptomatic, familial, perinatal and social correlates of computerised axial tomography (CAT) changes in schizophrenics and bipolar s. Journal of Nervous and Mental Disease, 173, 42–50.Google Scholar
Pocock, S. J. (1983) Clinical Trials: A Practical Approach. London: Wiley.Google Scholar
Reveley, A. M., Reveley, M. A. & Murray, R. M. (1984) Cerebral ventricular enlargement in non-genetic schizophrenia: a controlled twin study. British Journal of Psychiatry, 144, 89–93.Google Scholar
Roberts, J. (1980) The use of the CT scanner in psychiatry. MPhil Thesis, University of London.Google Scholar
Ron, M. A. (1983) The alcoholic brain: CT scan and psychological findings. Psychological Medicine Monograph (suppl. 3). Cambridge: Cambridge University Press.Google Scholar
Schulsinger, F., Parnas, J., Petersen, E. T., Schulsinger, H., Teasdale, T. W., Mednick, S. A., Moller, L. & Silverton, L. (1984) Cerebral ventricular size in the offspring of schizophrenic mothers. A preliminary study. Archives of General Psychiatry, 41, 602–606.Google Scholar
Smith, G. N. & Iacono, W. G. (1986) Lateral ventricular size in schizophrenia and choice of control group. The Lancet, i, 1450.Google Scholar
Spitzer, R. L., Endicott, J. & Robins, E. (1977) Research Diagnostic Criteria (RDC) for a Selected Group of Functional Disorders (3rd ed.) New York: New York State Psychiatric Institute.Google Scholar
Spitzer, R. L., & Endicott, J. (1978) Schedule for Affective Disorders and Schizophrenia. New York: New York State Psychiatric Institute.Google Scholar
Synek, V. & Reuben, J. R. (1976) The ventricular brain ratio using planimetric measurement of EMI scan. British Journal Radiology, 49, 233–237.Google Scholar
Thompson, W. D., Orvaschel, H., Prasoff, B. A. & Kidd, K. K. (1982) A evaluation of the Family History method for ascertaining psychiatric disorders. Archives of General Psychiatry, 39, 53–58.Google Scholar
Turner, S. W., Toone, B. K. & Brett-Jones, J. R. (1986) Computed tomographic scan changes in early schizophrenia – preliminary findings. Psychological Medicine, 16, 219–226.Google Scholar
Weinberger, D. R., Torrey, E. F., Neophytides, A. & Wyatt, R. J. (1979a) Lateral ventricular enlargement in chronic schizophrenia. Archives of General Psychiatry, 36, 735–739.Google Scholar
Weinberger, D. R., Torrey, E. F., Neophytides, A. & Wyatt, R. J. (1979b) Structural abnormalities in the cerebral cortex of chronic schizophrenic patients. Archives of General Psychiatry, 36, 935–939.Google Scholar
Weinberger, D. R., Torrey, E. F., Neophytides, A. & Wyatt, R. J. (1984) Computed tomography (CT) findings in schizophrenia. Speculation on the meaning of it all. Journal of Psychiatric Research, 18, 477–490.Google Scholar
Woerner, M. G., Pollack, M. & Klein, D. F. (1973) Pregnancy and birth complications in psychiatric patients: a comparison of schizophrenic and personality disorder patients with their siblings. Acta Psychiatrica Scandinavica, 49, 712.Google Scholar
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