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Predictors of Improvement in Tardive Dyskinesia Following Discontinuation of Neuroleptic Medication

Published online by Cambridge University Press:  02 January 2018

William M. Glazer ,
Hal Morgenstern ,
Nina Schooler ,
Cathy S. Berkman  and
Daniel C. Moore
William M. Glazer*
Affiliation:
Yale University School of Medicine, Director, TD Clinic
Hal Morgenstern
Affiliation:
UCLA School of Public Health
Nina Schooler
Affiliation:
Psychotic Disorders, Research Program, Department of Psychiatry, University of Pittsburgh, School of Medicine
Cathy S. Berkman
Affiliation:
Columbia University, School of Public Health
Daniel C. Moore
Affiliation:
Yale University School of Medicine
*
∗School of Medicine, Department of Psychiatry, 34 Park Street, New Haven, Connecticut 06519, USA
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Abstract

Forty-nine chronic psychiatric out-patients (ten were schizophrenic) with tardive dyskinesia (TD) were examined monthly for a mean of 40 weeks (range 1–59 months) after discontinuation of neuroleptic medication. Complete and persistent reversibility of TD was rare (2%), but many patients showed noticeable improvement in movements within the first year of discontinuation, which was sometimes interrupted by psychological relapse. Using three separate outcome measures and appropriate model-fitting techniques for each, we identified several predictors of improvement in TD, including an affective or schizoaffective psychiatric diagnosis, chronic (over 20 years) psychiatric illness, being employed, younger age, and increased neuroleptic dose before discontinuation. Consistent findings emerging from these analyses suggest that the type and history of psychiatric illness affect the course of TD.

Type
Papers
Information
The British Journal of Psychiatry , Volume 157 , Issue 4 , October 1990 , pp. 585 - 592
Copyright
Copyright © Royal College of Psychiatrists, 1990 

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