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Positive and Negative Symptoms

Relation to Familial Transmission of Schizophrenia

Published online by Cambridge University Press:  02 January 2018

Miron Baron ,
Rhoda S. Gruen  and
Joan M. Romo-Gruen
Miron Baron*
Affiliation:
Columbia University College of Physicians and Surgeons, and Director of Psychogenetics, Department of Medical Genetics, New York State Psychiatric Institute
Rhoda S. Gruen
Affiliation:
Columbia University College of Physicians and Surgeons, and Research Scientist, New York State Psychiatric Institute
Joan M. Romo-Gruen
Affiliation:
New York State Psychiatric Institute, USA
*
∗New York State Psychiatric Institute, 722 West 168th Street, New York, NY 10032, USA
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Abstract

The authors assessed the relevance of clinical symptoms to genetic research in schizophrenia in the nuclear families of 65 chronic schizophrenic probands. The morbidity risk for schizophrenia and schizotypal personality (a ‘spectrum’ disorder) was markedly reduced in first-degree relatives of probands with predominant negative symptoms, as compared with relatives of probands with other symptom patterns. The data support the notion that negative-symptom schizophrenia has an attenuated genetic component.

Type
Papers
Information
The British Journal of Psychiatry , Volume 161 , Issue 5 , November 1992 , pp. 610 - 614
Copyright
Copyright © 1992 The Royal College of Psychiatrists 

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