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Phenylalanine Tolerance in Endogenous Depression

Published online by Cambridge University Press:  29 January 2018

R. T. C. Pratt ,
Dawn Gardiner ,
G. Curzon ,
M. F. Piercy  and
J. N. Cumings
R. T. C. Pratt
Affiliation:
Maida Vale Hospital, London, W.9
Dawn Gardiner
Affiliation:
Department of Chemical Pathology, Institute of Neurology, London, W.C.1
G. Curzon
Affiliation:
Department of Chemical Pathology, Institute of Neurology, London, W.C.1
M. F. Piercy
Affiliation:
Maida Vale Hospital, London, W.9
J. N. Cumings
Affiliation:
Institute of Neurology, London, W.C.1
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Extract

Penrose (1935), in describing the first British patients with phenylketonuria, noted in their unaffected relatives a high incidence of paranoid illness in later life, and suggested that the heterozygous state might predispose to such breakdown. The 47 phenylketonuric families reported by Munro (1947) showed in unaffected relatives a similar high incidence of psychotic illness, which he (Munro, 1957) categorized as endogenous depression with paranoid features.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 109 , Issue 462 , September 1963 , pp. 624 - 628
Copyright
Copyright © Royal College of Psychiatrists, 1963 

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