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Neuroendocrine Challenges in the Diagnosis of Depressive Disorders

Published online by Cambridge University Press:  06 August 2018

J. J. López-Ibor Jr ,
J. Saiz-Ruiz  and
L. Moral Iglesias
J. J. López-Ibor Jr
Affiliation:
University of Alcalá de Henares, Spain
J. Saiz-Ruiz
Affiliation:
Psychiatric Teaching Unit, University of Alcalá de Henares, Madrid, Spain
L. Moral Iglesias
Affiliation:
Psychiatric Teaching Unit, University of Alcalá de Henares, Madrid, Spain
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Extract

An important topic in the neurobiology of the affective disorders relates to changes in the metabolism of neurotransmitters. Since the early 1960s, the ‘serotonergic’ hypothesis (Coppen et al, 1972) has been supported by findings such as a low concentration of 5-hydroxy-indoleacetic acid (5-HIAA) in the cerebro-spinal fluid (CSF) of patients with melancholic depression and/or suicidal behaviour (Banki & Arato, 1983; Åsberg et al, 1984; Banki et al, 1984; López-Ibor, Jr et al, 1985; Korpi et al, 1986) as well as the efficacy of serotonin precursors, when combined with MAOIs, in the treatment of depressed patients (Coppen et al, 1963; Glassman & Platman, 1969; Ayuso et al, 1971; López-Ibor, Jr et al, 1976).

Type
II. Biological Aspects
Information
The British Journal of Psychiatry , Volume 154 , Issue S4: Psychiatric Diagnosis: Nosological, Biological and Psychological Aspects , May 1989 , pp. 73 - 76
Copyright
Copyright © The Royal College of Psychiatrists 

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