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Minaprine in Depression

A Controlled Trial with Amitriptyline

Published online by Cambridge University Press:  02 January 2018

David Wheatley
David Wheatley*
Affiliation:
Psychopharmacology Research Group, 5 Warblers Green, Cobham, Surrey KT11 2NY
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Abstract

Minaprine (200 mg daily, either once or divided b.d.) was compared with amitriptyline (25–50 mg t.d.s.) over six weeks in 144 patients with major depression. Significant reductions in HRSD scores at the end of six weeks' treatment were recorded with both dose regimes of minaprine and with amitriptyline, with no significant differences between them. There was a significantly greater incidence of drowsiness and dry mouth with amitriptyline than with minaprine.

Type
Brief Reports
Information
The British Journal of Psychiatry , Volume 161 , Issue 1 , July 1992 , pp. 113 - 115
Copyright
Copyright © 1992 The Royal College of Psychiatrists 

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