Hostname: page-component-7b9c58cd5d-dlb68 Total loading time: 0 Render date: 2025-03-17T05:26:38.316Z Has data issue: false hasContentIssue false
  • English
  • Français

Mianserin Hydrochloride: A Novel Antidepressant

Published online by Cambridge University Press:  29 January 2018

Alec Coppen ,
Ramesh Gupta ,
Stuart Montgomery ,
Karabi Ghose ,
John Bailey ,
Bruce Burns  and
J. J. de Ridder
Alec Coppen
Affiliation:
MRC Neuropsychiatry Laboratory, West Park Hospital, Epsom, Surrey
Ramesh Gupta
Affiliation:
MRC Neuropsychiatry Laboratory, West Park Hospital, Epsom, Surrey
Stuart Montgomery
Affiliation:
MRC Neuropsychiatry Laboratory, West Park Hospital, Epsom, Surrey
Karabi Ghose
Affiliation:
MRC Neuropsychiatry Laboratory, West Park Hospital, Epsom, Surrey
John Bailey
Affiliation:
MRC Neuropsychiatry Laboratory, West Park Hospital, Epsom, Surrey
Bruce Burns
Affiliation:
Hollymoor Hospital, Birmingham
J. J. de Ridder
Affiliation:
Drug Metabolism R & D Laboratories, Organon, Oss, Holland
Get access Rights & Permissions [Opens in a new window]

Summary

The antidepressant activities of mianserin hydrochloride were investigated and compared with those of amitriptyline. The therapeutic efficacy of the two drugs appeared similar, but the incidence of side-effects was significantly higher with amitriptyline. Plasma levels of mianserin were determined during the trial and were not related to the therapeutic activity of the drug.

Type
Papers
Information
The British Journal of Psychiatry , Volume 129 , Issue 4 , October 1976 , pp. 342 - 345
Copyright
Copyright © Royal College of Psychiatrists, 1976 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Braithwaite, R. A., Goulding, R., Theano, G., Bailey, J. & Coppen, A. (1972) Plasma concentration of amitriptyline and clinical response. Lancet, i, 1297—1300.CrossRefGoogle Scholar
De Ridder, J. J. Advances in mass spectrometry. In Biochemistry and Medicine (ed. Frigerio, A.). New York: Spectrum Publications. In press.Google Scholar
Ghose, K., Coppen, A. & Turner, P. Autonomic actions and interactions of mianserin hydrochloride. Psychopharmacologia. In press.Google Scholar
Gurney, C., Roth, M., Garside, R. E., Kerr, T. A. & Schapira, A. (1972) Studies in the classification of affective disorders. The relationship between anxiety states and depressive illnesses. British Journal of Psychiatry, 123, 162—6.Google Scholar
Hamilton, M. J. (1960) A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 56—62.CrossRefGoogle ScholarPubMed
Hammar, C. G., Holmstedt, B. & Rhyhage, R. (1968) Mass fragmentography identification of chlorpromazine and its metabolites in human blood by a new method. Analytical Biochemistry, 25, 532—48.Google ScholarPubMed
Itil, I. M. (1973) Drug developments in Europe: discovery of ‘tetracyclic’ psychotropic drugs. Psychopharmacology Bulletin, 9, 41—3.Google Scholar
Kragh-S⊘rensen, P., Hansen, C. E. & Åsberg, M. (1973) Plasma nortriptyline levels in endogenous depression. Lancet, i, 113—15.Google Scholar
Palmai, G., Blackwell, B., Maxwell, A. E. & Morgestern, F. (1967) Patterns of salivary flow in depressive illness and during treatment. British Journal of Psychiatry, 113, 1297—1308.CrossRefGoogle Scholar
Sjöqvist, F. (1971) A pharmacokinetic approach to the treatment of depression. International Pharmacopsychiatry, 6, 147—69.CrossRefGoogle Scholar
Submit a response

eLetters

No eLetters have been published for this article.