Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-24T10:46:58.380Z Has data issue: false hasContentIssue false
  • English
  • Français

Manic Depressive Psychosis with Mental Retardation and Flexion Deformities

A Clinical and Cytogenetic Study

Published online by Cambridge University Press:  02 January 2018

A. H. Reid ,
A. J. G. Swanson ,
A. S. Jain ,
G. Spowart  and
A. F. Wright
A. H. Reid*
Affiliation:
Strathmartine Hospital, Dundee
A. J. G. Swanson
Affiliation:
University Department of Orthopaedic Surgery, Royal Infirmary, Dundee
A. S. Jain
Affiliation:
University Department of Orthopaedic Surgery, Royal Infirmary, Dundee
G. Spowart
Affiliation:
MRC Clinical and Population Cytogenetics Unit, Western General Hospital, Edinburgh
A. F. Wright
Affiliation:
MRC Clinical and Population Cytogenetics Unit, Western General Hospital, Crewe Road, Edinburgh
*
∗Correspondence
Get access Rights & Permissions [Opens in a new window]

Abstract

Five mentally handicapped patients are described in whom a bipolar manic depressive psychosis was associated with flexion deformities, involving principally the fingers. The effect of increasing degrees of retardation on the clinical presentation of the affective psychosis is discussed. Surgical treatment of the flexion deformity brought about considerable improvement in one patient. These five patients were further investigated cytogenetically using high resolution banding techniques. The results obtained were interesting but inconclusive. There would seem to be a definite place for further cytogenetic investigations of some of the more distinctive psychotic disorders using this technique.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 150 , Issue 1 , January 1987 , pp. 92 - 97
Copyright
Copyright © 1987 The Royal College of Psychiatrists 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Critchley, E. M. R., Vakil, S. D., Hayward, H. W. & Owen, V. M. H. (1976) Dupuytren's disease in epilepsy: result of prolonged administration of anticonvulsants. Journal of Neurology, Neurosurgery & Psychiatry, 39, 498–503.Google Scholar
Gershon, E. S. (1983) Genetics of the major psychoses. In Genetics of Neurological and Psychiatric Disorders (eds S. S. Kety, L. P. Rowland, R. L. Sidman & S. W. Matthysse). New York: Raven Press.Google Scholar
HGM 8 (1985) Eighth International Workshop on Human Gene Mapping. Cytogenetics and Cell Genetics, 40, 1–4.Google Scholar
ISCN (1985) An international system for human cytogenetic nomenclature. Birth Defects: Original Article Series, 21(1), 1–117.Google Scholar
Ikeuchi, T. (1984) Inhibitory effect of ethidium bromide on mitotic chromosome condensation and its application to high-resolution chromosome banding. Cytogenetics and Cell Genetics, 38,56–61.Google Scholar
Monaco, A. P., Bertelson, C. J., Middlesworth, W., Colletti, C., Aldridge, J. Fisch beck, K. H., Bartlett, R., Periczak-Fance, M. A., Roses, A. D. & Kunkel, L. M. (1985) Detection of deletions spanning the Duchenne muscular dystrophy locus using a tightly linked DNA segment. Nature, 316, 842–845.CrossRefGoogle ScholarPubMed
O'Rourke, D. H., McGuffin, P. & Reich, T. (1983) Genetic analysis of manic-depressive illness. American Journal of Physical Anthropology, 62, 51–59.Google Scholar
Reid, A. H. (1972) Psychoses in adult mental defectives: I. Manic depressive psychosis. British Journal of Psychiatry, 120, 205–212.Google Scholar
Reid, A. H. (1982) The Psychiatry of Mental Handicap. London: Blackwell Scientific Publications.Google Scholar
Reid, A. H. Naylor, G. J. & Kay, D. S. G. (1981) A double-blind, placebo controlled, crossover trial of carbamazepine in overactive, severely mentally handicapped patients. Psychological Medicine, 11, 109–113.Google Scholar
Rogers, D. (1985) The motor disorders of severe psychiatric illness: a conflict of paradigms. British Journal of Psychiatry, 147, 221–232.Google Scholar
Sumner, A. T., Evans, H. J. & Buckland, R. A. (1971) New techniques for distinguishing between human chromosomes. Nature New Biology, 232, 31–32.Google Scholar
Vogel, F. & Rathenberg, R. (1975) Spontaneous mutation in man. Advances in Human Genetics, 5, 223–318.Google Scholar
World Health Organization (1978) Medal Disorders: Glossary and Guide to the Classification in Accordance with the 9th Revision of the International Classification of Diseases. Geneva: WHO.Google Scholar
Yunis, J. J. (1976) High resolution of human chromosomes. Science 191, 1268–1270.Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.