Hostname: page-component-586b7cd67f-dlnhk Total loading time: 0 Render date: 2024-11-24T06:34:47.341Z Has data issue: false hasContentIssue false
  • English
  • Français

Investigation by Linkage Analysis of the XY Pseudoautosomal Region in the Genetic Susceptibility to Schizophrenia

Published online by Cambridge University Press:  02 January 2018

Gursharan Kalsi ,
David Curtis ,
Jon Brynjolfsson ,
Robert Butler ,
Tonmoy Sharma ,
Patrice Murphy ,
Tim Read ,
Hannes Petursson  and
Hugh M. D. Gurling
Gursharan Kalsi
Affiliation:
Molecular Psychiatry Laboratory, University College London Medical School
David Curtis
Affiliation:
Institute of Psychiatry, London
Jon Brynjolfsson
Affiliation:
Department of Psychiatry, University of Iceland
Robert Butler
Affiliation:
Molecular Psychiatry Laboratory, University College London Medical School
Tonmoy Sharma
Affiliation:
Molecular Psychiatry Laboratory, University College London Medical School
Patrice Murphy
Affiliation:
Molecular Psychiatry Laboratory, University College London Medical School
Tim Read
Affiliation:
Molecular Psychiatry Laboratory, University College London Medical School
Hannes Petursson
Affiliation:
Department of Psychiatry, University of Iceland
Hugh M. D. Gurling*
Affiliation:
Molecular Psychiatry Laboratory, University College London Medical School
*
Dr Gurling, Molecular Psychiatry Laboratory, Department of Psychiatry, University College London Medical School, Riding House Street, London W1P 7PN
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

A susceptibility locus for schizophrenia in the pseudoautosomal region has been proposed on the basis of a possible excess of sex chromosome aneuploidies among patients with schizophrenia and an increased sex concordance in affected sib pairs. Several studies investigating this hypothesis have produced conflicting evidence.

Method

In a series of Icelandic and British families, we used lod score and sib pair linkage analyses with markers for the MIC2 and DXYS14 loci on the pseudoautosomal XY region.

Results

Lod and sib pair linkage analysis with these markers produced strongly negative scores. Heterogeneity testing also produced negative results.

Conclusion

We conclude that the present study provides no support for the involvement of either the pseudoautosomal region or the nearby region of the sex chromosomes in the aetiology of schizophrenia.

Type
Papers
Information
The British Journal of Psychiatry , Volume 167 , Issue 3 , September 1995 , pp. 390 - 393
Copyright
Copyright © 1995 The Royal College of Psychiatrists

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Asherson, P., Parfitt, M., Sargeant, M., et al (1992) No evidence for a pseudoautosomal locus for schizophrenia. Linkage analysis of multiply affected families. British Journal of Psychiatry, 161, 63–68.10.1192/bjp.161.1.63Google Scholar
Barr, C. L., Kennedy, J. L., Pakstis, A. J., et al (1994) Linkage study of susceptibility locus for schizophrenia in the pseudoautosomal region. Schizophrenia Bulletin, 20, 277–286.10.1093/schbul/20.2.277Google Scholar
Collinge, J. S., DeLisi, L. E. & Boccio, A. (1991) Evidence for a pseudoautosomal locus for schizophrenia using the method of affected sib pairs. British Journal of Psychiatry, 158, 624–629.10.1192/bjp.158.5.624Google Scholar
Crow, T. J. (1988) Sex chromosomes and psychosis. The case for a pseudoautosomal locus. British Journal of Psychiatry, 153, 675–683.10.1192/bjp.153.5.675Google Scholar
Crow, T. J., DeLisi, L. E. & Johnstone, E. C. (1989) Concordance by sex in sibling pairs with schizophrenia is paternally inherited. Evidence for a pseudoautosomal locus. British Journal of Psychiatry, 155, 92–97.10.1192/bjp.155.1.92Google Scholar
Crow, T. J., DeLisi, L. E.Lofthouse, R., et al (1994) An examination of linkage of schizophrenia and schizoaffective disorder to the pseudoautosomal region (Xp22.3). British Journal of Psychiatry, 164, 159–164.10.1192/bjp.164.2.159Google Scholar
Curtis, D., Kalsi, G. & Gurling, H. M. D. (1994) Pseudoautosomal linkage in schizophrenia (letter). British Journal of Psychiatry, 165, 117–118.10.1192/bjp.165.1.117bGoogle Scholar
D'Amato, T., Campion, D., Gorwood, P., et al (1992) Evidence for a pseudoautosomal locus for schizophrenia II: Replication of a non-random segregation of alleles at the DXYS14 locus. British Journal of Psychiatry, 161, 59–62.10.1192/bjp.161.1.59Google Scholar
Gorwood, P., Leboyer, M., D'Amato, T., et al (1992) Evidence for a pseudoautosomal locus for schizophrenia I: A replication study using phenotype analysis. British Journal of Psychiatry, 161, 55–58.10.1192/bjp.161.1.55Google Scholar
Penrose, L. S. (1942) Auxiliary genes for determining sex as contributory causes of mental illness. Journal of Mental Science, 88, 308–316.10.1192/bjp.88.371.308Google Scholar
Wang, Z. W., Black, D., Andreasen, N., et al (1993) Pseudoautosomal locus for schizophrenia excluded in 12 pedigrees. Archives of General Psychiatry, 50, 199–204.10.1001/archpsyc.1993.01820150045004Google Scholar
Submit a response

eLetters

No eLetters have been published for this article.